A pilot study to evaluate the effects of C1 esterase inhibitor on the toxicity of high-dose interleukin 2.

In a pilot study six patients received 4 days' treatment with interleukin 2 (IL-2) [cumulative dose (CD) 264 +/- 26 x 10(6) IU m-2] and C1 esterase inhibitor (C1-INH) (loading dose 2,000 U, followed by 500-1,000 U twice daily). Toxicity was compared with that in patients given 4 days' trea...

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Autores principales: Ogilvie, A. C., Baars, J. W., Eerenberg, A. J., Hack, C. E., Pinedo, H. M., Thijs, L. G., Wagstaff, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968861/
https://www.ncbi.nlm.nih.gov/pubmed/8123494
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author Ogilvie, A. C.
Baars, J. W.
Eerenberg, A. J.
Hack, C. E.
Pinedo, H. M.
Thijs, L. G.
Wagstaff, J.
author_facet Ogilvie, A. C.
Baars, J. W.
Eerenberg, A. J.
Hack, C. E.
Pinedo, H. M.
Thijs, L. G.
Wagstaff, J.
author_sort Ogilvie, A. C.
collection PubMed
description In a pilot study six patients received 4 days' treatment with interleukin 2 (IL-2) [cumulative dose (CD) 264 +/- 26 x 10(6) IU m-2] and C1 esterase inhibitor (C1-INH) (loading dose 2,000 U, followed by 500-1,000 U twice daily). Toxicity was compared with that in patients given 4 days' treatment with standard (CD 66 +/- 12 x 10(6) IU m-2) or escalating-dose (CD 99 +/- 8 x 10(6) IU m-2) IL-2. IL-2-induced hypotension was equivalent and complement activation was less after IL-2 + C1-INH (C3a = 10.5 +/- 3.2 nmol l-1) than following standard (14.1 +/- 8.4 nmol l-1) or escalating-dose (18.3 +/- 2.9 nmol l-1) IL-2. This study demonstrates that C1-INH administration during IL-2 treatment is safe and warrants further study to evaluate its ability to ameliorate IL-2-induced toxicity.
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spelling pubmed-19688612009-09-10 A pilot study to evaluate the effects of C1 esterase inhibitor on the toxicity of high-dose interleukin 2. Ogilvie, A. C. Baars, J. W. Eerenberg, A. J. Hack, C. E. Pinedo, H. M. Thijs, L. G. Wagstaff, J. Br J Cancer Research Article In a pilot study six patients received 4 days' treatment with interleukin 2 (IL-2) [cumulative dose (CD) 264 +/- 26 x 10(6) IU m-2] and C1 esterase inhibitor (C1-INH) (loading dose 2,000 U, followed by 500-1,000 U twice daily). Toxicity was compared with that in patients given 4 days' treatment with standard (CD 66 +/- 12 x 10(6) IU m-2) or escalating-dose (CD 99 +/- 8 x 10(6) IU m-2) IL-2. IL-2-induced hypotension was equivalent and complement activation was less after IL-2 + C1-INH (C3a = 10.5 +/- 3.2 nmol l-1) than following standard (14.1 +/- 8.4 nmol l-1) or escalating-dose (18.3 +/- 2.9 nmol l-1) IL-2. This study demonstrates that C1-INH administration during IL-2 treatment is safe and warrants further study to evaluate its ability to ameliorate IL-2-induced toxicity. Nature Publishing Group 1994-03 /pmc/articles/PMC1968861/ /pubmed/8123494 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Ogilvie, A. C.
Baars, J. W.
Eerenberg, A. J.
Hack, C. E.
Pinedo, H. M.
Thijs, L. G.
Wagstaff, J.
A pilot study to evaluate the effects of C1 esterase inhibitor on the toxicity of high-dose interleukin 2.
title A pilot study to evaluate the effects of C1 esterase inhibitor on the toxicity of high-dose interleukin 2.
title_full A pilot study to evaluate the effects of C1 esterase inhibitor on the toxicity of high-dose interleukin 2.
title_fullStr A pilot study to evaluate the effects of C1 esterase inhibitor on the toxicity of high-dose interleukin 2.
title_full_unstemmed A pilot study to evaluate the effects of C1 esterase inhibitor on the toxicity of high-dose interleukin 2.
title_short A pilot study to evaluate the effects of C1 esterase inhibitor on the toxicity of high-dose interleukin 2.
title_sort pilot study to evaluate the effects of c1 esterase inhibitor on the toxicity of high-dose interleukin 2.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968861/
https://www.ncbi.nlm.nih.gov/pubmed/8123494
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