The prognostic significance of the accumulation of p53 tumour-suppressor gene protein in gastric adenocarcinoma.

We have studied the expression of p53 in 206 patients with gastric adenocarcinomas. A standard immunohistochemical technique employing the CM-1 anti-p53 polyclonal antibody was applied to the routinely fixed and paraffin-embedded material from these tumours; overexpression of p53 was defined as posi...

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Autores principales: Joypaul, B. V., Hopwood, D., Newman, E. L., Qureshi, S., Grant, A., Ogston, S. A., Lane, D. P., Cuschieri, A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968903/
https://www.ncbi.nlm.nih.gov/pubmed/8180028
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author Joypaul, B. V.
Hopwood, D.
Newman, E. L.
Qureshi, S.
Grant, A.
Ogston, S. A.
Lane, D. P.
Cuschieri, A.
author_facet Joypaul, B. V.
Hopwood, D.
Newman, E. L.
Qureshi, S.
Grant, A.
Ogston, S. A.
Lane, D. P.
Cuschieri, A.
author_sort Joypaul, B. V.
collection PubMed
description We have studied the expression of p53 in 206 patients with gastric adenocarcinomas. A standard immunohistochemical technique employing the CM-1 anti-p53 polyclonal antibody was applied to the routinely fixed and paraffin-embedded material from these tumours; overexpression of p53 was defined as positive nuclear staining: 46% (94/206) of gastric carcinomas expressed high levels of p53. There was no significant correlation between p53 positivity and the tumour grade, growth pattern, the Lauren type or lymph node metastases. Correlation with disease stage was only marginally significant (P = 0.05). Life table analysis revealed a highly significant association between p53 expression and survival (P = 0.0062), the odds ratio of death being 1.89 (95% confidence interval 1.33-2.69). The overall 5-year survival of patients with p53-positive tumours was 3% compared with 16% for those with p53-negative tumours (median survival time being 5.6 and 11.4 months respectively). These data suggest that overexpression of the p53 oncoprotein is an independent marker of shortened survival in gastric cancer patients. IMAGES:
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spelling pubmed-19689032009-09-10 The prognostic significance of the accumulation of p53 tumour-suppressor gene protein in gastric adenocarcinoma. Joypaul, B. V. Hopwood, D. Newman, E. L. Qureshi, S. Grant, A. Ogston, S. A. Lane, D. P. Cuschieri, A. Br J Cancer Research Article We have studied the expression of p53 in 206 patients with gastric adenocarcinomas. A standard immunohistochemical technique employing the CM-1 anti-p53 polyclonal antibody was applied to the routinely fixed and paraffin-embedded material from these tumours; overexpression of p53 was defined as positive nuclear staining: 46% (94/206) of gastric carcinomas expressed high levels of p53. There was no significant correlation between p53 positivity and the tumour grade, growth pattern, the Lauren type or lymph node metastases. Correlation with disease stage was only marginally significant (P = 0.05). Life table analysis revealed a highly significant association between p53 expression and survival (P = 0.0062), the odds ratio of death being 1.89 (95% confidence interval 1.33-2.69). The overall 5-year survival of patients with p53-positive tumours was 3% compared with 16% for those with p53-negative tumours (median survival time being 5.6 and 11.4 months respectively). These data suggest that overexpression of the p53 oncoprotein is an independent marker of shortened survival in gastric cancer patients. IMAGES: Nature Publishing Group 1994-05 /pmc/articles/PMC1968903/ /pubmed/8180028 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Joypaul, B. V.
Hopwood, D.
Newman, E. L.
Qureshi, S.
Grant, A.
Ogston, S. A.
Lane, D. P.
Cuschieri, A.
The prognostic significance of the accumulation of p53 tumour-suppressor gene protein in gastric adenocarcinoma.
title The prognostic significance of the accumulation of p53 tumour-suppressor gene protein in gastric adenocarcinoma.
title_full The prognostic significance of the accumulation of p53 tumour-suppressor gene protein in gastric adenocarcinoma.
title_fullStr The prognostic significance of the accumulation of p53 tumour-suppressor gene protein in gastric adenocarcinoma.
title_full_unstemmed The prognostic significance of the accumulation of p53 tumour-suppressor gene protein in gastric adenocarcinoma.
title_short The prognostic significance of the accumulation of p53 tumour-suppressor gene protein in gastric adenocarcinoma.
title_sort prognostic significance of the accumulation of p53 tumour-suppressor gene protein in gastric adenocarcinoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968903/
https://www.ncbi.nlm.nih.gov/pubmed/8180028
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