Anti-tumour activity of low-toxicity lipopolysaccharide of Bordetella pertussis.

A lipopolysaccharide (BP-LPS) isolated from killed Bordetella pertussis (Tohama strain) was determined to have low toxicity based on the mortality and decrease in body weight of BP-LPS-injected mice. BP-LPS, administered intradermally or intraperitoneally, clearly inhibited the growth of an MM46 mur...

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Autores principales: Ohnishi, M., Kimura, S., Yamazaki, M., Oshima, H., Mizuno, D. I., Abe, S., Yamaguchi, H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1969440/
https://www.ncbi.nlm.nih.gov/pubmed/8198967
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author Ohnishi, M.
Kimura, S.
Yamazaki, M.
Oshima, H.
Mizuno, D. I.
Abe, S.
Yamaguchi, H.
author_facet Ohnishi, M.
Kimura, S.
Yamazaki, M.
Oshima, H.
Mizuno, D. I.
Abe, S.
Yamaguchi, H.
author_sort Ohnishi, M.
collection PubMed
description A lipopolysaccharide (BP-LPS) isolated from killed Bordetella pertussis (Tohama strain) was determined to have low toxicity based on the mortality and decrease in body weight of BP-LPS-injected mice. BP-LPS, administered intradermally or intraperitoneally, clearly inhibited the growth of an MM46 murine mammary carcinoma. When compared with a toxic Escherichia coli-derived LPS, BP-LPS displayed excellent anti-tumour activity against MH134 hepatoma and Meth A fibrosarcoma. As part of a combined chemotherapy/immunotherapy regimen, BP-LPS also seemed to prolong the lifespan of mice inoculated with Lewis lung carcinoma. BP-LPS thus appears to have valuable characteristics as an anti-tumour agent.
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spelling pubmed-19694402009-09-10 Anti-tumour activity of low-toxicity lipopolysaccharide of Bordetella pertussis. Ohnishi, M. Kimura, S. Yamazaki, M. Oshima, H. Mizuno, D. I. Abe, S. Yamaguchi, H. Br J Cancer Research Article A lipopolysaccharide (BP-LPS) isolated from killed Bordetella pertussis (Tohama strain) was determined to have low toxicity based on the mortality and decrease in body weight of BP-LPS-injected mice. BP-LPS, administered intradermally or intraperitoneally, clearly inhibited the growth of an MM46 murine mammary carcinoma. When compared with a toxic Escherichia coli-derived LPS, BP-LPS displayed excellent anti-tumour activity against MH134 hepatoma and Meth A fibrosarcoma. As part of a combined chemotherapy/immunotherapy regimen, BP-LPS also seemed to prolong the lifespan of mice inoculated with Lewis lung carcinoma. BP-LPS thus appears to have valuable characteristics as an anti-tumour agent. Nature Publishing Group 1994-06 /pmc/articles/PMC1969440/ /pubmed/8198967 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Ohnishi, M.
Kimura, S.
Yamazaki, M.
Oshima, H.
Mizuno, D. I.
Abe, S.
Yamaguchi, H.
Anti-tumour activity of low-toxicity lipopolysaccharide of Bordetella pertussis.
title Anti-tumour activity of low-toxicity lipopolysaccharide of Bordetella pertussis.
title_full Anti-tumour activity of low-toxicity lipopolysaccharide of Bordetella pertussis.
title_fullStr Anti-tumour activity of low-toxicity lipopolysaccharide of Bordetella pertussis.
title_full_unstemmed Anti-tumour activity of low-toxicity lipopolysaccharide of Bordetella pertussis.
title_short Anti-tumour activity of low-toxicity lipopolysaccharide of Bordetella pertussis.
title_sort anti-tumour activity of low-toxicity lipopolysaccharide of bordetella pertussis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1969440/
https://www.ncbi.nlm.nih.gov/pubmed/8198967
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