Splanchnic blood flow changes in the presence of hepatic tumour: evidence of a humoral mediator.

Intrahepatic tumour is associated with alterations in splanchnic haemodynamics. To investigate the hypothesis that these are the result of a circulating vasoactive agent, rat small bowel segments were cross-perfused with arterial blood from groups (n = 12) of paired tumour-bearing (intrahepatic HSN...

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Detalles Bibliográficos
Autores principales: Carter, R., Anderson, J. H., Cooke, T. G., Baxter, J. N., Angerson, W. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1969452/
https://www.ncbi.nlm.nih.gov/pubmed/8198964
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author Carter, R.
Anderson, J. H.
Cooke, T. G.
Baxter, J. N.
Angerson, W. J.
author_facet Carter, R.
Anderson, J. H.
Cooke, T. G.
Baxter, J. N.
Angerson, W. J.
author_sort Carter, R.
collection PubMed
description Intrahepatic tumour is associated with alterations in splanchnic haemodynamics. To investigate the hypothesis that these are the result of a circulating vasoactive agent, rat small bowel segments were cross-perfused with arterial blood from groups (n = 12) of paired tumour-bearing (intrahepatic HSN sarcoma) and control rats. The vascular resistance of the segment was significantly greater during perfusion by tumour-bearing animals (91.6 mmHg ml-1 min, s.e. 21.5, vs 51.7 mmHg ml-1 min, s.e. 7.4, P < 0.05), suggesting that intrahepatic tumour may be associated with a circulating vasoactive agent. A similar mechanism may underlie changes in the hepatic perfusion index in patients with liver metastases.
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spelling pubmed-19694522009-09-10 Splanchnic blood flow changes in the presence of hepatic tumour: evidence of a humoral mediator. Carter, R. Anderson, J. H. Cooke, T. G. Baxter, J. N. Angerson, W. J. Br J Cancer Research Article Intrahepatic tumour is associated with alterations in splanchnic haemodynamics. To investigate the hypothesis that these are the result of a circulating vasoactive agent, rat small bowel segments were cross-perfused with arterial blood from groups (n = 12) of paired tumour-bearing (intrahepatic HSN sarcoma) and control rats. The vascular resistance of the segment was significantly greater during perfusion by tumour-bearing animals (91.6 mmHg ml-1 min, s.e. 21.5, vs 51.7 mmHg ml-1 min, s.e. 7.4, P < 0.05), suggesting that intrahepatic tumour may be associated with a circulating vasoactive agent. A similar mechanism may underlie changes in the hepatic perfusion index in patients with liver metastases. Nature Publishing Group 1994-06 /pmc/articles/PMC1969452/ /pubmed/8198964 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Carter, R.
Anderson, J. H.
Cooke, T. G.
Baxter, J. N.
Angerson, W. J.
Splanchnic blood flow changes in the presence of hepatic tumour: evidence of a humoral mediator.
title Splanchnic blood flow changes in the presence of hepatic tumour: evidence of a humoral mediator.
title_full Splanchnic blood flow changes in the presence of hepatic tumour: evidence of a humoral mediator.
title_fullStr Splanchnic blood flow changes in the presence of hepatic tumour: evidence of a humoral mediator.
title_full_unstemmed Splanchnic blood flow changes in the presence of hepatic tumour: evidence of a humoral mediator.
title_short Splanchnic blood flow changes in the presence of hepatic tumour: evidence of a humoral mediator.
title_sort splanchnic blood flow changes in the presence of hepatic tumour: evidence of a humoral mediator.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1969452/
https://www.ncbi.nlm.nih.gov/pubmed/8198964
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