Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence

BACKGROUND: The ATM protein is activated as a result of ionizing radiation, and genetic variants of the ATM gene may therefore affect the level of radiation-induced damage. Individuals heterozygous for ATM mutations have been reported to have an increased risk of malignancy, especially breast cancer...

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Detalles Bibliográficos
Autores principales: Edvardsen, Hege, Tefre, Toril, Jansen, Laila, Vu, Phuong, Haffty, Bruce G, Fosså, Sophie D, Kristensen, Vessela N, Børresen-Dale, Anne-Lise
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971057/
https://www.ncbi.nlm.nih.gov/pubmed/17623063
http://dx.doi.org/10.1186/1748-717X-2-25

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