Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression

BACKGROUND: In vivo studies on HIV-1 pathogenesis and testing of antiviral strategies have been hampered by the lack of an immunocompetent small animal model that is highly susceptible to HIV-1 infection. Since native rodents are non-permissive, we developed transgenic rats that selectively express...

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Detalles Bibliográficos
Autores principales: Goffinet, Christine, Michel, Nico, Allespach, Ina, Tervo, Hanna-Mari, Hermann, Volker, Kräusslich, Hans-Georg, Greene, Warner C, Keppler, Oliver T
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971067/
https://www.ncbi.nlm.nih.gov/pubmed/17655755
http://dx.doi.org/10.1186/1742-4690-4-53

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971067/
https://www.ncbi.nlm.nih.gov/pubmed/17655755
http://dx.doi.org/10.1186/1742-4690-4-53

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