Neurone specific enolase (NSE) in small cell lung cancer: a tumour marker of prognostic significance?

Pretreatment serum levels of neurone specific enolase (NSE) were measured in patients with small cell lung cancer (SCLC). Median values were significantly higher in patients with extensive compared with limited stage disease (48 ng ml-1 v. 17 ng ml-1: P less than 0.001). Serial NSE levels paralleled...

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Autores principales: Harding, M., McAllister, J., Hulks, G., Vernon, D., Monie, R., Paul, J., Kaye, S. B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1990
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971357/
https://www.ncbi.nlm.nih.gov/pubmed/2158809
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author Harding, M.
McAllister, J.
Hulks, G.
Vernon, D.
Monie, R.
Paul, J.
Kaye, S. B.
author_facet Harding, M.
McAllister, J.
Hulks, G.
Vernon, D.
Monie, R.
Paul, J.
Kaye, S. B.
author_sort Harding, M.
collection PubMed
description Pretreatment serum levels of neurone specific enolase (NSE) were measured in patients with small cell lung cancer (SCLC). Median values were significantly higher in patients with extensive compared with limited stage disease (48 ng ml-1 v. 17 ng ml-1: P less than 0.001). Serial NSE levels paralleled the clinical response to treatment. In 37 patients with limited SCLC, receiving identical chemotherapy, the pretreatment NSE level was of prognostic significance: with an approximate reduction in median survival of 10% for each 5 ng ml-1 incremental rise in NSE (P = 0.004).
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spelling pubmed-19713572009-09-10 Neurone specific enolase (NSE) in small cell lung cancer: a tumour marker of prognostic significance? Harding, M. McAllister, J. Hulks, G. Vernon, D. Monie, R. Paul, J. Kaye, S. B. Br J Cancer Research Article Pretreatment serum levels of neurone specific enolase (NSE) were measured in patients with small cell lung cancer (SCLC). Median values were significantly higher in patients with extensive compared with limited stage disease (48 ng ml-1 v. 17 ng ml-1: P less than 0.001). Serial NSE levels paralleled the clinical response to treatment. In 37 patients with limited SCLC, receiving identical chemotherapy, the pretreatment NSE level was of prognostic significance: with an approximate reduction in median survival of 10% for each 5 ng ml-1 incremental rise in NSE (P = 0.004). Nature Publishing Group 1990-04 /pmc/articles/PMC1971357/ /pubmed/2158809 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Harding, M.
McAllister, J.
Hulks, G.
Vernon, D.
Monie, R.
Paul, J.
Kaye, S. B.
Neurone specific enolase (NSE) in small cell lung cancer: a tumour marker of prognostic significance?
title Neurone specific enolase (NSE) in small cell lung cancer: a tumour marker of prognostic significance?
title_full Neurone specific enolase (NSE) in small cell lung cancer: a tumour marker of prognostic significance?
title_fullStr Neurone specific enolase (NSE) in small cell lung cancer: a tumour marker of prognostic significance?
title_full_unstemmed Neurone specific enolase (NSE) in small cell lung cancer: a tumour marker of prognostic significance?
title_short Neurone specific enolase (NSE) in small cell lung cancer: a tumour marker of prognostic significance?
title_sort neurone specific enolase (nse) in small cell lung cancer: a tumour marker of prognostic significance?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971357/
https://www.ncbi.nlm.nih.gov/pubmed/2158809
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