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Evidence for allosteric variants of wild-type p53, a tumour suppressor protein.
A tumour suppressor function for p53 is indicated in human lung cancer and in carcinoma of the colorectum. Loss of suppressor function, by mutation of the p53 gene, is associated with activation of p53 as an oncogene. The suppressor (wild type) and oncogenic (mutant) forms of the murine p53 protein...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
1990
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971359/ https://www.ncbi.nlm.nih.gov/pubmed/2139577 |