K20 and ICO-10 monoclonal antibodies (gp120/200; Thy-1): immunophenotyping of human solid tumours.

Solid tumour cells were shown to express VLA-beta and Thy-1 antigens. For identification of these molecules two monoclonal antibodies, K-20 and ICO-10, characterised in detail previously, were used. Four groups of solid tumours have been identified according to their immunophenotype: VLA-beta+ and T...

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Autores principales: Kadagidze, Z. G., Tupitsyn, N. N., Baryshnikov, A. J., Kadyrov, K. P., Blinov, V. M., Bernard, A., Amiot, M., Boumsell, L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1990
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971397/
https://www.ncbi.nlm.nih.gov/pubmed/1968760
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author Kadagidze, Z. G.
Tupitsyn, N. N.
Baryshnikov, A. J.
Kadyrov, K. P.
Blinov, V. M.
Bernard, A.
Amiot, M.
Boumsell, L.
author_facet Kadagidze, Z. G.
Tupitsyn, N. N.
Baryshnikov, A. J.
Kadyrov, K. P.
Blinov, V. M.
Bernard, A.
Amiot, M.
Boumsell, L.
author_sort Kadagidze, Z. G.
collection PubMed
description Solid tumour cells were shown to express VLA-beta and Thy-1 antigens. For identification of these molecules two monoclonal antibodies, K-20 and ICO-10, characterised in detail previously, were used. Four groups of solid tumours have been identified according to their immunophenotype: VLA-beta+ and Thy-1-; VLA-beta+ and Thy-1+; VLA-beta- and Thy-1+; VLA-beta- and Thy-1-. To a certain extent these groups have been shown to reflect tumour histogenesis: tumours of epithelial origin never expressed an ICO-10+, K20-phenotype while soft tissue sarcomas and neuroblastoma cells never expressed the beta-chain of VLA molecular complexes.
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spelling pubmed-19713972009-09-10 K20 and ICO-10 monoclonal antibodies (gp120/200; Thy-1): immunophenotyping of human solid tumours. Kadagidze, Z. G. Tupitsyn, N. N. Baryshnikov, A. J. Kadyrov, K. P. Blinov, V. M. Bernard, A. Amiot, M. Boumsell, L. Br J Cancer Research Article Solid tumour cells were shown to express VLA-beta and Thy-1 antigens. For identification of these molecules two monoclonal antibodies, K-20 and ICO-10, characterised in detail previously, were used. Four groups of solid tumours have been identified according to their immunophenotype: VLA-beta+ and Thy-1-; VLA-beta+ and Thy-1+; VLA-beta- and Thy-1+; VLA-beta- and Thy-1-. To a certain extent these groups have been shown to reflect tumour histogenesis: tumours of epithelial origin never expressed an ICO-10+, K20-phenotype while soft tissue sarcomas and neuroblastoma cells never expressed the beta-chain of VLA molecular complexes. Nature Publishing Group 1990-02 /pmc/articles/PMC1971397/ /pubmed/1968760 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Kadagidze, Z. G.
Tupitsyn, N. N.
Baryshnikov, A. J.
Kadyrov, K. P.
Blinov, V. M.
Bernard, A.
Amiot, M.
Boumsell, L.
K20 and ICO-10 monoclonal antibodies (gp120/200; Thy-1): immunophenotyping of human solid tumours.
title K20 and ICO-10 monoclonal antibodies (gp120/200; Thy-1): immunophenotyping of human solid tumours.
title_full K20 and ICO-10 monoclonal antibodies (gp120/200; Thy-1): immunophenotyping of human solid tumours.
title_fullStr K20 and ICO-10 monoclonal antibodies (gp120/200; Thy-1): immunophenotyping of human solid tumours.
title_full_unstemmed K20 and ICO-10 monoclonal antibodies (gp120/200; Thy-1): immunophenotyping of human solid tumours.
title_short K20 and ICO-10 monoclonal antibodies (gp120/200; Thy-1): immunophenotyping of human solid tumours.
title_sort k20 and ico-10 monoclonal antibodies (gp120/200; thy-1): immunophenotyping of human solid tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971397/
https://www.ncbi.nlm.nih.gov/pubmed/1968760
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