Preliminary observations on the microdistribution of labelled antibodies in human colonic adenocarcinoma xenografts: relevance to microdosimetry.

Autoradiography with 125I-labelled antibodies 17-1-A and 11-285-14 (anti-carcinoembryonic antigen) injected singly or together into nude mice carrying two distinct human colorectal cancer xenografts delineates marked changes in distribution and retention of isotope over 72 h, which are relevant to m...

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Autores principales: Pedley, R. B., Boxer, G. M., Boden, J. A., Southall, P. J., Begent, R. H., Bagshawe, K. D., Humm, J., Searle, F.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1990
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971400/
https://www.ncbi.nlm.nih.gov/pubmed/2310674
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author Pedley, R. B.
Boxer, G. M.
Boden, J. A.
Southall, P. J.
Begent, R. H.
Bagshawe, K. D.
Humm, J.
Searle, F.
author_facet Pedley, R. B.
Boxer, G. M.
Boden, J. A.
Southall, P. J.
Begent, R. H.
Bagshawe, K. D.
Humm, J.
Searle, F.
author_sort Pedley, R. B.
collection PubMed
description Autoradiography with 125I-labelled antibodies 17-1-A and 11-285-14 (anti-carcinoembryonic antigen) injected singly or together into nude mice carrying two distinct human colorectal cancer xenografts delineates marked changes in distribution and retention of isotope over 72 h, which are relevant to microdosimetry. The antibodies localise independently at low concentrations. Slow accumulation and retention predominantly in membranes of glands and necrotic areas suggest that therapy will succeed best with isotopes whose range, half-life and/or mode of delivery can exploit optimally the greater selectivity of the late retention. IMAGES:
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spelling pubmed-19714002009-09-10 Preliminary observations on the microdistribution of labelled antibodies in human colonic adenocarcinoma xenografts: relevance to microdosimetry. Pedley, R. B. Boxer, G. M. Boden, J. A. Southall, P. J. Begent, R. H. Bagshawe, K. D. Humm, J. Searle, F. Br J Cancer Research Article Autoradiography with 125I-labelled antibodies 17-1-A and 11-285-14 (anti-carcinoembryonic antigen) injected singly or together into nude mice carrying two distinct human colorectal cancer xenografts delineates marked changes in distribution and retention of isotope over 72 h, which are relevant to microdosimetry. The antibodies localise independently at low concentrations. Slow accumulation and retention predominantly in membranes of glands and necrotic areas suggest that therapy will succeed best with isotopes whose range, half-life and/or mode of delivery can exploit optimally the greater selectivity of the late retention. IMAGES: Nature Publishing Group 1990-02 /pmc/articles/PMC1971400/ /pubmed/2310674 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Pedley, R. B.
Boxer, G. M.
Boden, J. A.
Southall, P. J.
Begent, R. H.
Bagshawe, K. D.
Humm, J.
Searle, F.
Preliminary observations on the microdistribution of labelled antibodies in human colonic adenocarcinoma xenografts: relevance to microdosimetry.
title Preliminary observations on the microdistribution of labelled antibodies in human colonic adenocarcinoma xenografts: relevance to microdosimetry.
title_full Preliminary observations on the microdistribution of labelled antibodies in human colonic adenocarcinoma xenografts: relevance to microdosimetry.
title_fullStr Preliminary observations on the microdistribution of labelled antibodies in human colonic adenocarcinoma xenografts: relevance to microdosimetry.
title_full_unstemmed Preliminary observations on the microdistribution of labelled antibodies in human colonic adenocarcinoma xenografts: relevance to microdosimetry.
title_short Preliminary observations on the microdistribution of labelled antibodies in human colonic adenocarcinoma xenografts: relevance to microdosimetry.
title_sort preliminary observations on the microdistribution of labelled antibodies in human colonic adenocarcinoma xenografts: relevance to microdosimetry.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971400/
https://www.ncbi.nlm.nih.gov/pubmed/2310674
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