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Assessment of milk fat globule membrane antibodies and lectins as markers of short-term prognosis in breast cancer.
The milk fat globule membrane antibodies HMFG1, HMFG2, NCRC 11 and four of the Mam 6 series, and the lectins peanut agglutinin, wheat germ agglutinin, Concanavalin A, Lotus tetragonolobus and Ulex europaeus I have been applied to 115 stage I and II breast carcinomas (median follow up = 36 months) to...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1990
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971445/ https://www.ncbi.nlm.nih.gov/pubmed/2206956 |
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author | Walker, R. A. |
author_facet | Walker, R. A. |
author_sort | Walker, R. A. |
collection | PubMed |
description | The milk fat globule membrane antibodies HMFG1, HMFG2, NCRC 11 and four of the Mam 6 series, and the lectins peanut agglutinin, wheat germ agglutinin, Concanavalin A, Lotus tetragonolobus and Ulex europaeus I have been applied to 115 stage I and II breast carcinomas (median follow up = 36 months) to assess their value as prognostic markers. Of the milk fat globule membrane antibodies only NCRC 11 staining showed a relationship to development of recurrent disease and overall survival, but this did not act as an independent indicator over and above that provided by histological grade. None of the lectins gave prognostic information, including those whose binding related to node status or grade. It is concluded that for short-term prognosis none of the markers can given independent prognostic information over and above that provided by histological evaluation. |
format | Text |
id | pubmed-1971445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1990 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-19714452009-09-10 Assessment of milk fat globule membrane antibodies and lectins as markers of short-term prognosis in breast cancer. Walker, R. A. Br J Cancer Research Article The milk fat globule membrane antibodies HMFG1, HMFG2, NCRC 11 and four of the Mam 6 series, and the lectins peanut agglutinin, wheat germ agglutinin, Concanavalin A, Lotus tetragonolobus and Ulex europaeus I have been applied to 115 stage I and II breast carcinomas (median follow up = 36 months) to assess their value as prognostic markers. Of the milk fat globule membrane antibodies only NCRC 11 staining showed a relationship to development of recurrent disease and overall survival, but this did not act as an independent indicator over and above that provided by histological grade. None of the lectins gave prognostic information, including those whose binding related to node status or grade. It is concluded that for short-term prognosis none of the markers can given independent prognostic information over and above that provided by histological evaluation. Nature Publishing Group 1990-09 /pmc/articles/PMC1971445/ /pubmed/2206956 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Walker, R. A. Assessment of milk fat globule membrane antibodies and lectins as markers of short-term prognosis in breast cancer. |
title | Assessment of milk fat globule membrane antibodies and lectins as markers of short-term prognosis in breast cancer. |
title_full | Assessment of milk fat globule membrane antibodies and lectins as markers of short-term prognosis in breast cancer. |
title_fullStr | Assessment of milk fat globule membrane antibodies and lectins as markers of short-term prognosis in breast cancer. |
title_full_unstemmed | Assessment of milk fat globule membrane antibodies and lectins as markers of short-term prognosis in breast cancer. |
title_short | Assessment of milk fat globule membrane antibodies and lectins as markers of short-term prognosis in breast cancer. |
title_sort | assessment of milk fat globule membrane antibodies and lectins as markers of short-term prognosis in breast cancer. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971445/ https://www.ncbi.nlm.nih.gov/pubmed/2206956 |
work_keys_str_mv | AT walkerra assessmentofmilkfatglobulemembraneantibodiesandlectinsasmarkersofshorttermprognosisinbreastcancer |