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Serum oestrogen levels in postmenopausal women: comparison of American whites and Japanese in Japan.

Serum oestrone (E1), oestradiol (E2) and sex hormone binding globulin (SHBG) levels were studied in postmenopausal Japanese women in Japan (n = 91) and postmenopausal American white women (n = 38). The Japanese women were deliberately chosen to be from a rural agricultural area in order to get sampl...

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Detalles Bibliográficos
Autores principales: Shimizu, H., Ross, R. K., Bernstein, L., Pike, M. C., Henderson, B. E.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1990
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971457/
https://www.ncbi.nlm.nih.gov/pubmed/2206953
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author Shimizu, H.
Ross, R. K.
Bernstein, L.
Pike, M. C.
Henderson, B. E.
author_facet Shimizu, H.
Ross, R. K.
Bernstein, L.
Pike, M. C.
Henderson, B. E.
author_sort Shimizu, H.
collection PubMed
description Serum oestrone (E1), oestradiol (E2) and sex hormone binding globulin (SHBG) levels were studied in postmenopausal Japanese women in Japan (n = 91) and postmenopausal American white women (n = 38). The Japanese women were deliberately chosen to be from a rural agricultural area in order to get samples which represent as closely as possible the traditional Japanese 'lifestyle' that gave rise to the low rates of breast cancer in Japan. E1 levels were 47%, and E2 levels 36%, greater in the American women; these differences were only reduced to 43% and 27% after adjustment for the lower weight of the Japanese. These results were all statistically highly significant. There was little difference in SHBG levels between the Japanese and the American women. These results for E1 and E2 could be an important part of the explanation why Japanese and American breast cancer rates continue to diverge further after the menopause.
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spelling pubmed-19714572009-09-10 Serum oestrogen levels in postmenopausal women: comparison of American whites and Japanese in Japan. Shimizu, H. Ross, R. K. Bernstein, L. Pike, M. C. Henderson, B. E. Br J Cancer Research Article Serum oestrone (E1), oestradiol (E2) and sex hormone binding globulin (SHBG) levels were studied in postmenopausal Japanese women in Japan (n = 91) and postmenopausal American white women (n = 38). The Japanese women were deliberately chosen to be from a rural agricultural area in order to get samples which represent as closely as possible the traditional Japanese 'lifestyle' that gave rise to the low rates of breast cancer in Japan. E1 levels were 47%, and E2 levels 36%, greater in the American women; these differences were only reduced to 43% and 27% after adjustment for the lower weight of the Japanese. These results were all statistically highly significant. There was little difference in SHBG levels between the Japanese and the American women. These results for E1 and E2 could be an important part of the explanation why Japanese and American breast cancer rates continue to diverge further after the menopause. Nature Publishing Group 1990-09 /pmc/articles/PMC1971457/ /pubmed/2206953 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Shimizu, H.
Ross, R. K.
Bernstein, L.
Pike, M. C.
Henderson, B. E.
Serum oestrogen levels in postmenopausal women: comparison of American whites and Japanese in Japan.
title Serum oestrogen levels in postmenopausal women: comparison of American whites and Japanese in Japan.
title_full Serum oestrogen levels in postmenopausal women: comparison of American whites and Japanese in Japan.
title_fullStr Serum oestrogen levels in postmenopausal women: comparison of American whites and Japanese in Japan.
title_full_unstemmed Serum oestrogen levels in postmenopausal women: comparison of American whites and Japanese in Japan.
title_short Serum oestrogen levels in postmenopausal women: comparison of American whites and Japanese in Japan.
title_sort serum oestrogen levels in postmenopausal women: comparison of american whites and japanese in japan.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971457/
https://www.ncbi.nlm.nih.gov/pubmed/2206953
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