The inhibition of cellular recovery in human tumour cells by inhibitors of topoisomerase.

A human bladder carcinoma cell line was irradiated at high and low dose rates and exposed to camptothecin and VP16, inhibitors of topoisomerase I and topoisomerase II respectively. Although camptothecin substantially modified the cytotoxic effects of high dose rate irradiation, abolished low dose ra...

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Detalles Bibliográficos
Autores principales: Musk, S. R., Steel, G. G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1990
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971459/
https://www.ncbi.nlm.nih.gov/pubmed/2169851
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author Musk, S. R.
Steel, G. G.
author_facet Musk, S. R.
Steel, G. G.
author_sort Musk, S. R.
collection PubMed
description A human bladder carcinoma cell line was irradiated at high and low dose rates and exposed to camptothecin and VP16, inhibitors of topoisomerase I and topoisomerase II respectively. Although camptothecin substantially modified the cytotoxic effects of high dose rate irradiation, abolished low dose rate sparing and inhibited the repair of sublethal and potentially lethal damage, VP16 had no effect on the survival curves even at highly cytotoxic doses. Thus, it is argued that there is a role for topoisomerase I but not topoisomerase II in the repair of DNA damage induced by ionising radiation.
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spelling pubmed-19714592009-09-10 The inhibition of cellular recovery in human tumour cells by inhibitors of topoisomerase. Musk, S. R. Steel, G. G. Br J Cancer Research Article A human bladder carcinoma cell line was irradiated at high and low dose rates and exposed to camptothecin and VP16, inhibitors of topoisomerase I and topoisomerase II respectively. Although camptothecin substantially modified the cytotoxic effects of high dose rate irradiation, abolished low dose rate sparing and inhibited the repair of sublethal and potentially lethal damage, VP16 had no effect on the survival curves even at highly cytotoxic doses. Thus, it is argued that there is a role for topoisomerase I but not topoisomerase II in the repair of DNA damage induced by ionising radiation. Nature Publishing Group 1990-09 /pmc/articles/PMC1971459/ /pubmed/2169851 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Musk, S. R.
Steel, G. G.
The inhibition of cellular recovery in human tumour cells by inhibitors of topoisomerase.
title The inhibition of cellular recovery in human tumour cells by inhibitors of topoisomerase.
title_full The inhibition of cellular recovery in human tumour cells by inhibitors of topoisomerase.
title_fullStr The inhibition of cellular recovery in human tumour cells by inhibitors of topoisomerase.
title_full_unstemmed The inhibition of cellular recovery in human tumour cells by inhibitors of topoisomerase.
title_short The inhibition of cellular recovery in human tumour cells by inhibitors of topoisomerase.
title_sort inhibition of cellular recovery in human tumour cells by inhibitors of topoisomerase.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971459/
https://www.ncbi.nlm.nih.gov/pubmed/2169851
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