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Serum CA125 level is a good prognostic indicator in lung cancer.
The serum CA125 level was determined by a one-step immunoradiometric assay method in patients with lung cancer. Increased serum CA125 levels were observed in 37.8% of patients with squamous cell cancer, in 30.0% of those with adenocarcinoma and in 60.0% of those with small call cancer. Most patients...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1990
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971475/ https://www.ncbi.nlm.nih.gov/pubmed/2223590 |
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author | Kimura, Y. Fujii, T. Hamamoto, K. Miyagawa, N. Kataoka, M. Iio, A. |
author_facet | Kimura, Y. Fujii, T. Hamamoto, K. Miyagawa, N. Kataoka, M. Iio, A. |
author_sort | Kimura, Y. |
collection | PubMed |
description | The serum CA125 level was determined by a one-step immunoradiometric assay method in patients with lung cancer. Increased serum CA125 levels were observed in 37.8% of patients with squamous cell cancer, in 30.0% of those with adenocarcinoma and in 60.0% of those with small call cancer. Most patients with increased serum CA125 levels were in stages 3 or 4. Patients with pleural effusions or ascites showed high serum CA125 levels. The survival time was significantly shorter in patients with increased serum CA125 levels than in those within normal limits. Among patients with advanced disease (stages 3 and 4), an increased serum CA125 level was again a poor prognostic factor (P less than 0.01). The existence of a pleural effusion did not correlate with the survival time. We conclude that CA125 is a good indicator of disease extent and serum levels correlate to the length of survival. |
format | Text |
id | pubmed-1971475 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1990 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-19714752009-09-10 Serum CA125 level is a good prognostic indicator in lung cancer. Kimura, Y. Fujii, T. Hamamoto, K. Miyagawa, N. Kataoka, M. Iio, A. Br J Cancer Research Article The serum CA125 level was determined by a one-step immunoradiometric assay method in patients with lung cancer. Increased serum CA125 levels were observed in 37.8% of patients with squamous cell cancer, in 30.0% of those with adenocarcinoma and in 60.0% of those with small call cancer. Most patients with increased serum CA125 levels were in stages 3 or 4. Patients with pleural effusions or ascites showed high serum CA125 levels. The survival time was significantly shorter in patients with increased serum CA125 levels than in those within normal limits. Among patients with advanced disease (stages 3 and 4), an increased serum CA125 level was again a poor prognostic factor (P less than 0.01). The existence of a pleural effusion did not correlate with the survival time. We conclude that CA125 is a good indicator of disease extent and serum levels correlate to the length of survival. Nature Publishing Group 1990-10 /pmc/articles/PMC1971475/ /pubmed/2223590 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Kimura, Y. Fujii, T. Hamamoto, K. Miyagawa, N. Kataoka, M. Iio, A. Serum CA125 level is a good prognostic indicator in lung cancer. |
title | Serum CA125 level is a good prognostic indicator in lung cancer. |
title_full | Serum CA125 level is a good prognostic indicator in lung cancer. |
title_fullStr | Serum CA125 level is a good prognostic indicator in lung cancer. |
title_full_unstemmed | Serum CA125 level is a good prognostic indicator in lung cancer. |
title_short | Serum CA125 level is a good prognostic indicator in lung cancer. |
title_sort | serum ca125 level is a good prognostic indicator in lung cancer. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971475/ https://www.ncbi.nlm.nih.gov/pubmed/2223590 |
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