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Squamous cell carcinoma: infiltrating monocyte/macrophage subpopulations express functional mature phenotype.
Biopsies from 26 patients with advanced stage squamous cell carcinoma of the head and neck were investigated to determine the intensity of the inflammatory cellular infiltrate and the expression of leucocyte antigens. Mononuclear cell infiltration varied considerably between the individual patients...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1990
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971517/ https://www.ncbi.nlm.nih.gov/pubmed/2147109 |
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author | Neuchrist, C. Grasl, M. Scheiner, O. Lassmann, H. Ehrenberger, K. Kraft, D. |
author_facet | Neuchrist, C. Grasl, M. Scheiner, O. Lassmann, H. Ehrenberger, K. Kraft, D. |
author_sort | Neuchrist, C. |
collection | PubMed |
description | Biopsies from 26 patients with advanced stage squamous cell carcinoma of the head and neck were investigated to determine the intensity of the inflammatory cellular infiltrate and the expression of leucocyte antigens. Mononuclear cell infiltration varied considerably between the individual patients and also within the tumour. Tumour-infiltrating cells consisted mainly of T lymphocytes and monocytes (Mo)/macrophages (M phi). Staining procedure with monoclonal antibodies (moabs) against Mo/M phi revealed different clusters of antigen expression: (1) moabs 27E10 and a-CD35 detected a subgroup of Mo/M phi with particular staining of perivasal Mo; (2) moab a-CD1 stained preferentially cells in tumour cell clusters; (3) moabs that reacted with cells of either typical M phi or dendritic morphology throughout the tumour-tissue: a-Fc gamma receptor I-III, a-class II antigens, a-CD4, Rm3/1, a-CD36 and 25F9. Thus, the majority of tumour-infiltrating mononuclear phagocytes were found to possess a rather mature phenotype. The number of Mo/M phi with mature phenotype within the tumours correlated with T lymphocyte infiltration in the tissue. IMAGES: |
format | Text |
id | pubmed-1971517 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1990 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-19715172009-09-10 Squamous cell carcinoma: infiltrating monocyte/macrophage subpopulations express functional mature phenotype. Neuchrist, C. Grasl, M. Scheiner, O. Lassmann, H. Ehrenberger, K. Kraft, D. Br J Cancer Research Article Biopsies from 26 patients with advanced stage squamous cell carcinoma of the head and neck were investigated to determine the intensity of the inflammatory cellular infiltrate and the expression of leucocyte antigens. Mononuclear cell infiltration varied considerably between the individual patients and also within the tumour. Tumour-infiltrating cells consisted mainly of T lymphocytes and monocytes (Mo)/macrophages (M phi). Staining procedure with monoclonal antibodies (moabs) against Mo/M phi revealed different clusters of antigen expression: (1) moabs 27E10 and a-CD35 detected a subgroup of Mo/M phi with particular staining of perivasal Mo; (2) moab a-CD1 stained preferentially cells in tumour cell clusters; (3) moabs that reacted with cells of either typical M phi or dendritic morphology throughout the tumour-tissue: a-Fc gamma receptor I-III, a-class II antigens, a-CD4, Rm3/1, a-CD36 and 25F9. Thus, the majority of tumour-infiltrating mononuclear phagocytes were found to possess a rather mature phenotype. The number of Mo/M phi with mature phenotype within the tumours correlated with T lymphocyte infiltration in the tissue. IMAGES: Nature Publishing Group 1990-11 /pmc/articles/PMC1971517/ /pubmed/2147109 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Neuchrist, C. Grasl, M. Scheiner, O. Lassmann, H. Ehrenberger, K. Kraft, D. Squamous cell carcinoma: infiltrating monocyte/macrophage subpopulations express functional mature phenotype. |
title | Squamous cell carcinoma: infiltrating monocyte/macrophage subpopulations express functional mature phenotype. |
title_full | Squamous cell carcinoma: infiltrating monocyte/macrophage subpopulations express functional mature phenotype. |
title_fullStr | Squamous cell carcinoma: infiltrating monocyte/macrophage subpopulations express functional mature phenotype. |
title_full_unstemmed | Squamous cell carcinoma: infiltrating monocyte/macrophage subpopulations express functional mature phenotype. |
title_short | Squamous cell carcinoma: infiltrating monocyte/macrophage subpopulations express functional mature phenotype. |
title_sort | squamous cell carcinoma: infiltrating monocyte/macrophage subpopulations express functional mature phenotype. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971517/ https://www.ncbi.nlm.nih.gov/pubmed/2147109 |
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