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The prognostic value of DNA-ploidy in colorectal carcinoma: a prospective study.

One hundred and fifty-seven patients with usual colorectal cancer were analysed prospectively for DNA-ploidy, DNA-index and S-phase fraction (SPF) using flow cytometry. An abnormal DNA-stemline was observed in 68% of tumours. The patients have been followed for a median of 36 months. In univariate a...

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Autores principales: Kouri, M., Pyrhönen, S., Mecklin, J. P., Järvinen, H., Laasonen, A., Franssila, K., Nordling, S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1990
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971551/
https://www.ncbi.nlm.nih.gov/pubmed/2257229
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author Kouri, M.
Pyrhönen, S.
Mecklin, J. P.
Järvinen, H.
Laasonen, A.
Franssila, K.
Nordling, S.
author_facet Kouri, M.
Pyrhönen, S.
Mecklin, J. P.
Järvinen, H.
Laasonen, A.
Franssila, K.
Nordling, S.
author_sort Kouri, M.
collection PubMed
description One hundred and fifty-seven patients with usual colorectal cancer were analysed prospectively for DNA-ploidy, DNA-index and S-phase fraction (SPF) using flow cytometry. An abnormal DNA-stemline was observed in 68% of tumours. The patients have been followed for a median of 36 months. In univariate analysis, tumour stage was the most significant prognostic factor. After excluding patients with stage D disease, DNA-aneuploidy was significantly associated with a shorter survival and a shorter disease free survival. SPF, however, did not correlate with prognosis. In multiple samples from the same tumour there was on average a 29% difference between the highest and the lowest SPF indicating considerable heterogeneity in proliferative activity within the tumours. In diploid tumours the variation was even higher. Patients with proximal tumours as well as female patients had DNA-diploid tumours more often than the others. This may indicate that there are different, so far unknown, aetiological factors leading to different types of ploidy pattern.
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spelling pubmed-19715512009-09-10 The prognostic value of DNA-ploidy in colorectal carcinoma: a prospective study. Kouri, M. Pyrhönen, S. Mecklin, J. P. Järvinen, H. Laasonen, A. Franssila, K. Nordling, S. Br J Cancer Research Article One hundred and fifty-seven patients with usual colorectal cancer were analysed prospectively for DNA-ploidy, DNA-index and S-phase fraction (SPF) using flow cytometry. An abnormal DNA-stemline was observed in 68% of tumours. The patients have been followed for a median of 36 months. In univariate analysis, tumour stage was the most significant prognostic factor. After excluding patients with stage D disease, DNA-aneuploidy was significantly associated with a shorter survival and a shorter disease free survival. SPF, however, did not correlate with prognosis. In multiple samples from the same tumour there was on average a 29% difference between the highest and the lowest SPF indicating considerable heterogeneity in proliferative activity within the tumours. In diploid tumours the variation was even higher. Patients with proximal tumours as well as female patients had DNA-diploid tumours more often than the others. This may indicate that there are different, so far unknown, aetiological factors leading to different types of ploidy pattern. Nature Publishing Group 1990-12 /pmc/articles/PMC1971551/ /pubmed/2257229 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Kouri, M.
Pyrhönen, S.
Mecklin, J. P.
Järvinen, H.
Laasonen, A.
Franssila, K.
Nordling, S.
The prognostic value of DNA-ploidy in colorectal carcinoma: a prospective study.
title The prognostic value of DNA-ploidy in colorectal carcinoma: a prospective study.
title_full The prognostic value of DNA-ploidy in colorectal carcinoma: a prospective study.
title_fullStr The prognostic value of DNA-ploidy in colorectal carcinoma: a prospective study.
title_full_unstemmed The prognostic value of DNA-ploidy in colorectal carcinoma: a prospective study.
title_short The prognostic value of DNA-ploidy in colorectal carcinoma: a prospective study.
title_sort prognostic value of dna-ploidy in colorectal carcinoma: a prospective study.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971551/
https://www.ncbi.nlm.nih.gov/pubmed/2257229
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