Distribution of pimonidazole and RSU 1069 in tumour and normal tissues.

The tritium-labelled analogues of pimonidazole and RSU 1069 were injected into mice bearing the KHT murine sarcoma which has a hypoxic cell fraction of approximately 10%. The distribution of activity at 24 h was recorded using autoradiography and measurement of tissue activity. Autoradiographs with...

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Autores principales: Cobb, L. M., Nolan, J., Butler, S. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1990
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971577/
https://www.ncbi.nlm.nih.gov/pubmed/2257219
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author Cobb, L. M.
Nolan, J.
Butler, S. A.
author_facet Cobb, L. M.
Nolan, J.
Butler, S. A.
author_sort Cobb, L. M.
collection PubMed
description The tritium-labelled analogues of pimonidazole and RSU 1069 were injected into mice bearing the KHT murine sarcoma which has a hypoxic cell fraction of approximately 10%. The distribution of activity at 24 h was recorded using autoradiography and measurement of tissue activity. Autoradiographs with both drugs showed high activity in particular cells within tumour, eye (melanin-associated cells), eyelid (Meibomian gland), liver (centrilobular area), skin (sebaceous gland and melanin), stomach (squamous area), footpad, oesophagus, labial gland, Zymbal's gland, preputial gland, parotid gland (intralobular ducts) and airway epithelium. These tissues had previously been identified as sites of binding of misonidazole. The measurement of total tissue radioactivity showed significantly higher activity in liver, eyelid (Meibomian gland), oesophageal lining, kidney and labial gland than was found in the tumour. IMAGES:
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spelling pubmed-19715772009-09-10 Distribution of pimonidazole and RSU 1069 in tumour and normal tissues. Cobb, L. M. Nolan, J. Butler, S. A. Br J Cancer Research Article The tritium-labelled analogues of pimonidazole and RSU 1069 were injected into mice bearing the KHT murine sarcoma which has a hypoxic cell fraction of approximately 10%. The distribution of activity at 24 h was recorded using autoradiography and measurement of tissue activity. Autoradiographs with both drugs showed high activity in particular cells within tumour, eye (melanin-associated cells), eyelid (Meibomian gland), liver (centrilobular area), skin (sebaceous gland and melanin), stomach (squamous area), footpad, oesophagus, labial gland, Zymbal's gland, preputial gland, parotid gland (intralobular ducts) and airway epithelium. These tissues had previously been identified as sites of binding of misonidazole. The measurement of total tissue radioactivity showed significantly higher activity in liver, eyelid (Meibomian gland), oesophageal lining, kidney and labial gland than was found in the tumour. IMAGES: Nature Publishing Group 1990-12 /pmc/articles/PMC1971577/ /pubmed/2257219 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Cobb, L. M.
Nolan, J.
Butler, S. A.
Distribution of pimonidazole and RSU 1069 in tumour and normal tissues.
title Distribution of pimonidazole and RSU 1069 in tumour and normal tissues.
title_full Distribution of pimonidazole and RSU 1069 in tumour and normal tissues.
title_fullStr Distribution of pimonidazole and RSU 1069 in tumour and normal tissues.
title_full_unstemmed Distribution of pimonidazole and RSU 1069 in tumour and normal tissues.
title_short Distribution of pimonidazole and RSU 1069 in tumour and normal tissues.
title_sort distribution of pimonidazole and rsu 1069 in tumour and normal tissues.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971577/
https://www.ncbi.nlm.nih.gov/pubmed/2257219
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