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Serum human alpha-lactalbumin as a marker for breast cancer.
Serum levels of alpha-lactalbumin were assayed using a monoclonal antibody specific for this breast specific molecule. Elevated levels were found in 87% (48/55) of sera from women in the third trimester of pregnancy (29.1 +/- 7.4 ng ml-1), from 64% (62/97) of patients with breast cancer (23.4 +/- 5....
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1990
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971622/ https://www.ncbi.nlm.nih.gov/pubmed/2337516 |
Sumario: | Serum levels of alpha-lactalbumin were assayed using a monoclonal antibody specific for this breast specific molecule. Elevated levels were found in 87% (48/55) of sera from women in the third trimester of pregnancy (29.1 +/- 7.4 ng ml-1), from 64% (62/97) of patients with breast cancer (23.4 +/- 5.6 ng ml-1), and from 70% (56/80) of patients with gynaecological cancers (19.4 +/- 6.7 ng ml-1). These alpha-lactalbumin levels were significantly higher (P less than 0.001) than those for men and non-pregnant women (11.0 +/- 2.3 ng ml-1) and for patients with other, non-gynaecological cancers (13.4 +/- 3.6 ng ml-1). The alpha-lactalbumin levels were higher in patients with stage IV breast cancer than those with stage I-III breast cancer. The overall sensitivity and specificity of the radioimmunoassay were 72% and 75% respectively. These findings suggest that the assessment of serum levels of alpha-lactalbumin may be useful as a marker for monitoring breast cancer. IMAGES: |
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