Serum human alpha-lactalbumin as a marker for breast cancer.

Serum levels of alpha-lactalbumin were assayed using a monoclonal antibody specific for this breast specific molecule. Elevated levels were found in 87% (48/55) of sera from women in the third trimester of pregnancy (29.1 +/- 7.4 ng ml-1), from 64% (62/97) of patients with breast cancer (23.4 +/- 5....

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Autores principales: Thean, E. T., Toh, B. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1990
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971622/
https://www.ncbi.nlm.nih.gov/pubmed/2337516
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author Thean, E. T.
Toh, B. H.
author_facet Thean, E. T.
Toh, B. H.
author_sort Thean, E. T.
collection PubMed
description Serum levels of alpha-lactalbumin were assayed using a monoclonal antibody specific for this breast specific molecule. Elevated levels were found in 87% (48/55) of sera from women in the third trimester of pregnancy (29.1 +/- 7.4 ng ml-1), from 64% (62/97) of patients with breast cancer (23.4 +/- 5.6 ng ml-1), and from 70% (56/80) of patients with gynaecological cancers (19.4 +/- 6.7 ng ml-1). These alpha-lactalbumin levels were significantly higher (P less than 0.001) than those for men and non-pregnant women (11.0 +/- 2.3 ng ml-1) and for patients with other, non-gynaecological cancers (13.4 +/- 3.6 ng ml-1). The alpha-lactalbumin levels were higher in patients with stage IV breast cancer than those with stage I-III breast cancer. The overall sensitivity and specificity of the radioimmunoassay were 72% and 75% respectively. These findings suggest that the assessment of serum levels of alpha-lactalbumin may be useful as a marker for monitoring breast cancer. IMAGES:
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spelling pubmed-19716222009-09-10 Serum human alpha-lactalbumin as a marker for breast cancer. Thean, E. T. Toh, B. H. Br J Cancer Research Article Serum levels of alpha-lactalbumin were assayed using a monoclonal antibody specific for this breast specific molecule. Elevated levels were found in 87% (48/55) of sera from women in the third trimester of pregnancy (29.1 +/- 7.4 ng ml-1), from 64% (62/97) of patients with breast cancer (23.4 +/- 5.6 ng ml-1), and from 70% (56/80) of patients with gynaecological cancers (19.4 +/- 6.7 ng ml-1). These alpha-lactalbumin levels were significantly higher (P less than 0.001) than those for men and non-pregnant women (11.0 +/- 2.3 ng ml-1) and for patients with other, non-gynaecological cancers (13.4 +/- 3.6 ng ml-1). The alpha-lactalbumin levels were higher in patients with stage IV breast cancer than those with stage I-III breast cancer. The overall sensitivity and specificity of the radioimmunoassay were 72% and 75% respectively. These findings suggest that the assessment of serum levels of alpha-lactalbumin may be useful as a marker for monitoring breast cancer. IMAGES: Nature Publishing Group 1990-05 /pmc/articles/PMC1971622/ /pubmed/2337516 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Thean, E. T.
Toh, B. H.
Serum human alpha-lactalbumin as a marker for breast cancer.
title Serum human alpha-lactalbumin as a marker for breast cancer.
title_full Serum human alpha-lactalbumin as a marker for breast cancer.
title_fullStr Serum human alpha-lactalbumin as a marker for breast cancer.
title_full_unstemmed Serum human alpha-lactalbumin as a marker for breast cancer.
title_short Serum human alpha-lactalbumin as a marker for breast cancer.
title_sort serum human alpha-lactalbumin as a marker for breast cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971622/
https://www.ncbi.nlm.nih.gov/pubmed/2337516
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