Pleiotropic-resistant phenotype is a multifactorial phenomenon in human colon carcinoma cell lines.

The biochemical basis of multidrug-resistant (MDR) phenotype has been investigated in drug-resistant sublines independently obtained in our laboratories by single step doxorubicin (DOX) selection of LoVo, DLD1, and SW948 human colon carcinoma (HCC) cell lines. All the chemoresistant sublines have be...

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Autores principales: Toffoli, G., Viel, A., Tumiotto, L., Biscontin, G., Rossi, C., Boiocchi, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971628/
https://www.ncbi.nlm.nih.gov/pubmed/1671208
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author Toffoli, G.
Viel, A.
Tumiotto, L.
Biscontin, G.
Rossi, C.
Boiocchi, M.
author_facet Toffoli, G.
Viel, A.
Tumiotto, L.
Biscontin, G.
Rossi, C.
Boiocchi, M.
author_sort Toffoli, G.
collection PubMed
description The biochemical basis of multidrug-resistant (MDR) phenotype has been investigated in drug-resistant sublines independently obtained in our laboratories by single step doxorubicin (DOX) selection of LoVo, DLD1, and SW948 human colon carcinoma (HCC) cell lines. All the chemoresistant sublines have been found to be cross-resistant to DOX, actinomycin-D (ACT-D) and vincristine (VCR) but not to cis-diamminedichloroplatinum (CDDP), and have exhibited an increased expression level of mdr1 mRNA and gp170 glycoprotein. Comparative analyses in drug-resistant and sensitive cells of resistance index, extracellular and intracellular equitoxic DOX concentrations, and mdr1 gene products expression have indicated that MDR phenotype is a multifactorial phenomenon due to different and possibly independent biochemical mechanisms which cooperate, in varying degrees from cell line to cell line, in conferring cellular chemoresistance. IMAGES:
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spelling pubmed-19716282009-09-10 Pleiotropic-resistant phenotype is a multifactorial phenomenon in human colon carcinoma cell lines. Toffoli, G. Viel, A. Tumiotto, L. Biscontin, G. Rossi, C. Boiocchi, M. Br J Cancer Research Article The biochemical basis of multidrug-resistant (MDR) phenotype has been investigated in drug-resistant sublines independently obtained in our laboratories by single step doxorubicin (DOX) selection of LoVo, DLD1, and SW948 human colon carcinoma (HCC) cell lines. All the chemoresistant sublines have been found to be cross-resistant to DOX, actinomycin-D (ACT-D) and vincristine (VCR) but not to cis-diamminedichloroplatinum (CDDP), and have exhibited an increased expression level of mdr1 mRNA and gp170 glycoprotein. Comparative analyses in drug-resistant and sensitive cells of resistance index, extracellular and intracellular equitoxic DOX concentrations, and mdr1 gene products expression have indicated that MDR phenotype is a multifactorial phenomenon due to different and possibly independent biochemical mechanisms which cooperate, in varying degrees from cell line to cell line, in conferring cellular chemoresistance. IMAGES: Nature Publishing Group 1991-01 /pmc/articles/PMC1971628/ /pubmed/1671208 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Toffoli, G.
Viel, A.
Tumiotto, L.
Biscontin, G.
Rossi, C.
Boiocchi, M.
Pleiotropic-resistant phenotype is a multifactorial phenomenon in human colon carcinoma cell lines.
title Pleiotropic-resistant phenotype is a multifactorial phenomenon in human colon carcinoma cell lines.
title_full Pleiotropic-resistant phenotype is a multifactorial phenomenon in human colon carcinoma cell lines.
title_fullStr Pleiotropic-resistant phenotype is a multifactorial phenomenon in human colon carcinoma cell lines.
title_full_unstemmed Pleiotropic-resistant phenotype is a multifactorial phenomenon in human colon carcinoma cell lines.
title_short Pleiotropic-resistant phenotype is a multifactorial phenomenon in human colon carcinoma cell lines.
title_sort pleiotropic-resistant phenotype is a multifactorial phenomenon in human colon carcinoma cell lines.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971628/
https://www.ncbi.nlm.nih.gov/pubmed/1671208
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