Manipulation of body fat composition with sterculic acid can inhibit mammary carcinomas in vivo.

Sterculic acid, a delta-9-desaturase inhibitor, administered to rats caused a rise in the stearic:oleic acid ratio of total lipids in peripheral red cells, serum and liver (P less than 0.001). As a reduction in the stearic:oleic acid ratio has been described in cancer cells, we investigated the effe...

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Autores principales: Khoo, D. E., Fermor, B., Miller, J., Wood, C. B., Apostolov, K., Barker, W., Williamson, R. C., Habib, N. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971644/
https://www.ncbi.nlm.nih.gov/pubmed/1989672
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author Khoo, D. E.
Fermor, B.
Miller, J.
Wood, C. B.
Apostolov, K.
Barker, W.
Williamson, R. C.
Habib, N. A.
author_facet Khoo, D. E.
Fermor, B.
Miller, J.
Wood, C. B.
Apostolov, K.
Barker, W.
Williamson, R. C.
Habib, N. A.
author_sort Khoo, D. E.
collection PubMed
description Sterculic acid, a delta-9-desaturase inhibitor, administered to rats caused a rise in the stearic:oleic acid ratio of total lipids in peripheral red cells, serum and liver (P less than 0.001). As a reduction in the stearic:oleic acid ratio has been described in cancer cells, we investigated the effect of sterculic acid on tumour growth. Female F344 rats were injected subcutaneously with two different doses of sterculic acid for 4 weeks prior to, and 4 weeks following, implantation of a nitrosomethylurea-induced mammary tumour. Tumour growth was inhibited equally by the two doses of sterculic acid (P less than 0.001). A rise in the stearic:oleic acid ratio of tumours was observed in rats treated for only 16 days with sterculic acid. Manipulation of the tissue stearic:oleic acid ratio inhibits transplanted mammary tumour growth in rats.
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spelling pubmed-19716442009-09-10 Manipulation of body fat composition with sterculic acid can inhibit mammary carcinomas in vivo. Khoo, D. E. Fermor, B. Miller, J. Wood, C. B. Apostolov, K. Barker, W. Williamson, R. C. Habib, N. A. Br J Cancer Research Article Sterculic acid, a delta-9-desaturase inhibitor, administered to rats caused a rise in the stearic:oleic acid ratio of total lipids in peripheral red cells, serum and liver (P less than 0.001). As a reduction in the stearic:oleic acid ratio has been described in cancer cells, we investigated the effect of sterculic acid on tumour growth. Female F344 rats were injected subcutaneously with two different doses of sterculic acid for 4 weeks prior to, and 4 weeks following, implantation of a nitrosomethylurea-induced mammary tumour. Tumour growth was inhibited equally by the two doses of sterculic acid (P less than 0.001). A rise in the stearic:oleic acid ratio of tumours was observed in rats treated for only 16 days with sterculic acid. Manipulation of the tissue stearic:oleic acid ratio inhibits transplanted mammary tumour growth in rats. Nature Publishing Group 1991-01 /pmc/articles/PMC1971644/ /pubmed/1989672 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Khoo, D. E.
Fermor, B.
Miller, J.
Wood, C. B.
Apostolov, K.
Barker, W.
Williamson, R. C.
Habib, N. A.
Manipulation of body fat composition with sterculic acid can inhibit mammary carcinomas in vivo.
title Manipulation of body fat composition with sterculic acid can inhibit mammary carcinomas in vivo.
title_full Manipulation of body fat composition with sterculic acid can inhibit mammary carcinomas in vivo.
title_fullStr Manipulation of body fat composition with sterculic acid can inhibit mammary carcinomas in vivo.
title_full_unstemmed Manipulation of body fat composition with sterculic acid can inhibit mammary carcinomas in vivo.
title_short Manipulation of body fat composition with sterculic acid can inhibit mammary carcinomas in vivo.
title_sort manipulation of body fat composition with sterculic acid can inhibit mammary carcinomas in vivo.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971644/
https://www.ncbi.nlm.nih.gov/pubmed/1989672
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