Occurrence of neuron specific enolase in tumour tissue and serum in small cell lung cancer.

An analysis has been made of the relationship between neuron specific enolase (NSE) in serum and immunohistochemically identified occurrence of NSE in the primary tumour in 56 patients with small cell lung cancer (SCLC). Patients were referred to the Finsen Institute for treatment during a period of...

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Autores principales: Jørgensen, L. G., Hirsch, F. R., Skov, B. G., Osterlind, K., Cooper, E. H., Larsson, L. I.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971651/
https://www.ncbi.nlm.nih.gov/pubmed/1703432
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author Jørgensen, L. G.
Hirsch, F. R.
Skov, B. G.
Osterlind, K.
Cooper, E. H.
Larsson, L. I.
author_facet Jørgensen, L. G.
Hirsch, F. R.
Skov, B. G.
Osterlind, K.
Cooper, E. H.
Larsson, L. I.
author_sort Jørgensen, L. G.
collection PubMed
description An analysis has been made of the relationship between neuron specific enolase (NSE) in serum and immunohistochemically identified occurrence of NSE in the primary tumour in 56 patients with small cell lung cancer (SCLC). Patients were referred to the Finsen Institute for treatment during a period of 18 months. Forty-six tumours (82%) were NSE positive. To compare this staining with the occurrence of NSE in serum, a histological staining index (HSI) was established by semiquantitative gradation of the staining. No significant differences were found between distribution of serum NSE values in different HSI categories, and a high ranking in HSI was not associated with a high level of serum NSE. Both univariate and multivariate analysis selected serum NSE and not HSI as the most influential prognostic factor in SCLC. IMAGES:
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spelling pubmed-19716512009-09-10 Occurrence of neuron specific enolase in tumour tissue and serum in small cell lung cancer. Jørgensen, L. G. Hirsch, F. R. Skov, B. G. Osterlind, K. Cooper, E. H. Larsson, L. I. Br J Cancer Research Article An analysis has been made of the relationship between neuron specific enolase (NSE) in serum and immunohistochemically identified occurrence of NSE in the primary tumour in 56 patients with small cell lung cancer (SCLC). Patients were referred to the Finsen Institute for treatment during a period of 18 months. Forty-six tumours (82%) were NSE positive. To compare this staining with the occurrence of NSE in serum, a histological staining index (HSI) was established by semiquantitative gradation of the staining. No significant differences were found between distribution of serum NSE values in different HSI categories, and a high ranking in HSI was not associated with a high level of serum NSE. Both univariate and multivariate analysis selected serum NSE and not HSI as the most influential prognostic factor in SCLC. IMAGES: Nature Publishing Group 1991-01 /pmc/articles/PMC1971651/ /pubmed/1703432 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Jørgensen, L. G.
Hirsch, F. R.
Skov, B. G.
Osterlind, K.
Cooper, E. H.
Larsson, L. I.
Occurrence of neuron specific enolase in tumour tissue and serum in small cell lung cancer.
title Occurrence of neuron specific enolase in tumour tissue and serum in small cell lung cancer.
title_full Occurrence of neuron specific enolase in tumour tissue and serum in small cell lung cancer.
title_fullStr Occurrence of neuron specific enolase in tumour tissue and serum in small cell lung cancer.
title_full_unstemmed Occurrence of neuron specific enolase in tumour tissue and serum in small cell lung cancer.
title_short Occurrence of neuron specific enolase in tumour tissue and serum in small cell lung cancer.
title_sort occurrence of neuron specific enolase in tumour tissue and serum in small cell lung cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971651/
https://www.ncbi.nlm.nih.gov/pubmed/1703432
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