Glutathione S-transferase expression in fetal kidney and Wilms' tumour.

The glutathione S-transferases (GSTs) have been implicated in carcinogenesis and tumour drug-therapy resistance. In this study GST pi was the predominant isoenzyme in the fetal human kidney. It was present in differentiated epithelial structures but never in the primitive mesenchyme. By contrast mos...

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Autores principales: Harrison, D. J., Hallam, L., Lauder, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1990
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971671/
https://www.ncbi.nlm.nih.gov/pubmed/2164834
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author Harrison, D. J.
Hallam, L.
Lauder, J.
author_facet Harrison, D. J.
Hallam, L.
Lauder, J.
author_sort Harrison, D. J.
collection PubMed
description The glutathione S-transferases (GSTs) have been implicated in carcinogenesis and tumour drug-therapy resistance. In this study GST pi was the predominant isoenzyme in the fetal human kidney. It was present in differentiated epithelial structures but never in the primitive mesenchyme. By contrast most cases of Wilms' tumours showed GST pi in both epithelial structures and undifferentiated blastema. The level of expression, as assessed by immunostaining, was no more than moderate, and was generally higher in differentiated elements. In only one case was GST alpha found in Wilms' tumour. This study had demonstrated a difference between fetal kidney and Wilms' tumour blastema in terms of GST expression. IMAGES:
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spelling pubmed-19716712009-09-10 Glutathione S-transferase expression in fetal kidney and Wilms' tumour. Harrison, D. J. Hallam, L. Lauder, J. Br J Cancer Research Article The glutathione S-transferases (GSTs) have been implicated in carcinogenesis and tumour drug-therapy resistance. In this study GST pi was the predominant isoenzyme in the fetal human kidney. It was present in differentiated epithelial structures but never in the primitive mesenchyme. By contrast most cases of Wilms' tumours showed GST pi in both epithelial structures and undifferentiated blastema. The level of expression, as assessed by immunostaining, was no more than moderate, and was generally higher in differentiated elements. In only one case was GST alpha found in Wilms' tumour. This study had demonstrated a difference between fetal kidney and Wilms' tumour blastema in terms of GST expression. IMAGES: Nature Publishing Group 1990-06 /pmc/articles/PMC1971671/ /pubmed/2164834 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Harrison, D. J.
Hallam, L.
Lauder, J.
Glutathione S-transferase expression in fetal kidney and Wilms' tumour.
title Glutathione S-transferase expression in fetal kidney and Wilms' tumour.
title_full Glutathione S-transferase expression in fetal kidney and Wilms' tumour.
title_fullStr Glutathione S-transferase expression in fetal kidney and Wilms' tumour.
title_full_unstemmed Glutathione S-transferase expression in fetal kidney and Wilms' tumour.
title_short Glutathione S-transferase expression in fetal kidney and Wilms' tumour.
title_sort glutathione s-transferase expression in fetal kidney and wilms' tumour.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971671/
https://www.ncbi.nlm.nih.gov/pubmed/2164834
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AT lauderj glutathionestransferaseexpressioninfetalkidneyandwilmstumour

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