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Mortality by laterality of the primary tumour among 55,000 breast cancer patients from the Swedish Cancer Registry.

To examine the hypothesis that radiotherapy for breast cancer can cause myocardial infarction, cause-specific mortality by laterality of the primary tumour was analysed among 54,617 breast cancer patients reported to the Swedish Cancer Registry during 1970-1985. The rationale was that radiotherapy f...

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Autores principales: Rutqvist, L. E., Johansson, H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1990
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971705/
https://www.ncbi.nlm.nih.gov/pubmed/2372488
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author Rutqvist, L. E.
Johansson, H.
author_facet Rutqvist, L. E.
Johansson, H.
author_sort Rutqvist, L. E.
collection PubMed
description To examine the hypothesis that radiotherapy for breast cancer can cause myocardial infarction, cause-specific mortality by laterality of the primary tumour was analysed among 54,617 breast cancer patients reported to the Swedish Cancer Registry during 1970-1985. The rationale was that radiotherapy for a left-sided breast cancer invariably results in higher doses of radiation to the myocardium than a similar treatment given for a right-sided tumour whereas other possible risk factors for cardiovascular disease probably are unrelated to the laterality of the tumour. The median follow-up was 9 years (range 1-17 years). Patients with left-sided tumours were found to have a higher mortality due to myocardial infarction than patients with right-sided tumours (P less than 0.01) but there was no difference in regard to total intercurrent mortality. Further analyses of individual radiotherapy studies are warranted to quantify the excess risk associated with radiation and to study the significance of the type of radiation, portal arrangements, total dose and fractionation. It seems reasonable to assume that adverse effects of radiation are dose-related and may thus be minimised or prevented by the use of appropriate treatment techniques.
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spelling pubmed-19717052009-09-10 Mortality by laterality of the primary tumour among 55,000 breast cancer patients from the Swedish Cancer Registry. Rutqvist, L. E. Johansson, H. Br J Cancer Research Article To examine the hypothesis that radiotherapy for breast cancer can cause myocardial infarction, cause-specific mortality by laterality of the primary tumour was analysed among 54,617 breast cancer patients reported to the Swedish Cancer Registry during 1970-1985. The rationale was that radiotherapy for a left-sided breast cancer invariably results in higher doses of radiation to the myocardium than a similar treatment given for a right-sided tumour whereas other possible risk factors for cardiovascular disease probably are unrelated to the laterality of the tumour. The median follow-up was 9 years (range 1-17 years). Patients with left-sided tumours were found to have a higher mortality due to myocardial infarction than patients with right-sided tumours (P less than 0.01) but there was no difference in regard to total intercurrent mortality. Further analyses of individual radiotherapy studies are warranted to quantify the excess risk associated with radiation and to study the significance of the type of radiation, portal arrangements, total dose and fractionation. It seems reasonable to assume that adverse effects of radiation are dose-related and may thus be minimised or prevented by the use of appropriate treatment techniques. Nature Publishing Group 1990-06 /pmc/articles/PMC1971705/ /pubmed/2372488 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Rutqvist, L. E.
Johansson, H.
Mortality by laterality of the primary tumour among 55,000 breast cancer patients from the Swedish Cancer Registry.
title Mortality by laterality of the primary tumour among 55,000 breast cancer patients from the Swedish Cancer Registry.
title_full Mortality by laterality of the primary tumour among 55,000 breast cancer patients from the Swedish Cancer Registry.
title_fullStr Mortality by laterality of the primary tumour among 55,000 breast cancer patients from the Swedish Cancer Registry.
title_full_unstemmed Mortality by laterality of the primary tumour among 55,000 breast cancer patients from the Swedish Cancer Registry.
title_short Mortality by laterality of the primary tumour among 55,000 breast cancer patients from the Swedish Cancer Registry.
title_sort mortality by laterality of the primary tumour among 55,000 breast cancer patients from the swedish cancer registry.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971705/
https://www.ncbi.nlm.nih.gov/pubmed/2372488
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