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The implication of dihydrofolate reductase and dihydropteroate synthetase gene mutations in modification of Plasmodium falciparum characteristics

BACKGROUND: The Plasmodium falciparum dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) are enzymes of central importance in parasite metabolism. The dhfr and dhps gene mutations are known to be associated with sulphadoxine/pyrimethamine (SP) resistance. OBJECTIVE: To investigate...

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Detalles Bibliográficos
Autores principales:	A-Elbasit, Ishraga E, Alifrangis, Michael, Khalil, Insaf F, Bygbjerg, Ib C, Masuadi, Emad M, Elbashir, Mustafa I, Giha, Hayder A
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971711/ https://www.ncbi.nlm.nih.gov/pubmed/17686173 http://dx.doi.org/10.1186/1475-2875-6-108

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