Cyclosporin A and verapamil have different effects on energy metabolism in multidrug-resistant tumour cells.

Cyclosporin A (Sandimmune) rapidly induced an increase in daunorubicin accumulation in multidrug-resistant human ovarian carcinoma cells (2780AD) and was more potent than verapamil. Steady-state 3H-cyclosporin A accumulation at 37 degrees C in 2780AD cells was 60-70% of that in the sensitive A2780 c...

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Autores principales: Broxterman, H. J., Pinedo, H. M., Schuurhuis, G. J., Lankelma, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1990
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971735/
https://www.ncbi.nlm.nih.gov/pubmed/2390489
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author Broxterman, H. J.
Pinedo, H. M.
Schuurhuis, G. J.
Lankelma, J.
author_facet Broxterman, H. J.
Pinedo, H. M.
Schuurhuis, G. J.
Lankelma, J.
author_sort Broxterman, H. J.
collection PubMed
description Cyclosporin A (Sandimmune) rapidly induced an increase in daunorubicin accumulation in multidrug-resistant human ovarian carcinoma cells (2780AD) and was more potent than verapamil. Steady-state 3H-cyclosporin A accumulation at 37 degrees C in 2780AD cells was 60-70% of that in the sensitive A2780 cells. A rapid increase of ATP consumption and lactate production was induced in 2780AD cells by verapamil, but not by cyclosporin A. These results suggest that the interactions of cyclosporin A and verapamil with P-glycoprotein, which leads to inhibition of drug transport, have a different mechanistic basis.
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spelling pubmed-19717352009-09-10 Cyclosporin A and verapamil have different effects on energy metabolism in multidrug-resistant tumour cells. Broxterman, H. J. Pinedo, H. M. Schuurhuis, G. J. Lankelma, J. Br J Cancer Research Article Cyclosporin A (Sandimmune) rapidly induced an increase in daunorubicin accumulation in multidrug-resistant human ovarian carcinoma cells (2780AD) and was more potent than verapamil. Steady-state 3H-cyclosporin A accumulation at 37 degrees C in 2780AD cells was 60-70% of that in the sensitive A2780 cells. A rapid increase of ATP consumption and lactate production was induced in 2780AD cells by verapamil, but not by cyclosporin A. These results suggest that the interactions of cyclosporin A and verapamil with P-glycoprotein, which leads to inhibition of drug transport, have a different mechanistic basis. Nature Publishing Group 1990-07 /pmc/articles/PMC1971735/ /pubmed/2390489 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Broxterman, H. J.
Pinedo, H. M.
Schuurhuis, G. J.
Lankelma, J.
Cyclosporin A and verapamil have different effects on energy metabolism in multidrug-resistant tumour cells.
title Cyclosporin A and verapamil have different effects on energy metabolism in multidrug-resistant tumour cells.
title_full Cyclosporin A and verapamil have different effects on energy metabolism in multidrug-resistant tumour cells.
title_fullStr Cyclosporin A and verapamil have different effects on energy metabolism in multidrug-resistant tumour cells.
title_full_unstemmed Cyclosporin A and verapamil have different effects on energy metabolism in multidrug-resistant tumour cells.
title_short Cyclosporin A and verapamil have different effects on energy metabolism in multidrug-resistant tumour cells.
title_sort cyclosporin a and verapamil have different effects on energy metabolism in multidrug-resistant tumour cells.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971735/
https://www.ncbi.nlm.nih.gov/pubmed/2390489
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