Photodynamic therapy of a mouse glioma: intracranial tumours are resistant while subcutaneous tumours are sensitive.

Subcutaneous and intracranial VMDk tumours were treated with photodynamic therapy (PDT) using a new sensitiser, m-THPP. Subcutaneous tumours were highly sensitive to PDT but intracranial tumours were much more resistant, requiring a 30-fold increase in sensitiser dose to produce equivalent levels of...

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Autores principales: Lindsay, E. A., Berenbaum, M. C., Bonnett, R., Thomas, D. G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971766/
https://www.ncbi.nlm.nih.gov/pubmed/1997101
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author Lindsay, E. A.
Berenbaum, M. C.
Bonnett, R.
Thomas, D. G.
author_facet Lindsay, E. A.
Berenbaum, M. C.
Bonnett, R.
Thomas, D. G.
author_sort Lindsay, E. A.
collection PubMed
description Subcutaneous and intracranial VMDk tumours were treated with photodynamic therapy (PDT) using a new sensitiser, m-THPP. Subcutaneous tumours were highly sensitive to PDT but intracranial tumours were much more resistant, requiring a 30-fold increase in sensitiser dose to produce equivalent levels of necrosis. Resistance of intracerebral tumours was not due to failure of the sensitiser to enter tumours. Necrosis of intracranial tumours was increased when mice breathed 100% oxygen during PDT while subcutaneous tumour necrosis was unaffected.
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spelling pubmed-19717662009-09-10 Photodynamic therapy of a mouse glioma: intracranial tumours are resistant while subcutaneous tumours are sensitive. Lindsay, E. A. Berenbaum, M. C. Bonnett, R. Thomas, D. G. Br J Cancer Research Article Subcutaneous and intracranial VMDk tumours were treated with photodynamic therapy (PDT) using a new sensitiser, m-THPP. Subcutaneous tumours were highly sensitive to PDT but intracranial tumours were much more resistant, requiring a 30-fold increase in sensitiser dose to produce equivalent levels of necrosis. Resistance of intracerebral tumours was not due to failure of the sensitiser to enter tumours. Necrosis of intracranial tumours was increased when mice breathed 100% oxygen during PDT while subcutaneous tumour necrosis was unaffected. Nature Publishing Group 1991-02 /pmc/articles/PMC1971766/ /pubmed/1997101 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Lindsay, E. A.
Berenbaum, M. C.
Bonnett, R.
Thomas, D. G.
Photodynamic therapy of a mouse glioma: intracranial tumours are resistant while subcutaneous tumours are sensitive.
title Photodynamic therapy of a mouse glioma: intracranial tumours are resistant while subcutaneous tumours are sensitive.
title_full Photodynamic therapy of a mouse glioma: intracranial tumours are resistant while subcutaneous tumours are sensitive.
title_fullStr Photodynamic therapy of a mouse glioma: intracranial tumours are resistant while subcutaneous tumours are sensitive.
title_full_unstemmed Photodynamic therapy of a mouse glioma: intracranial tumours are resistant while subcutaneous tumours are sensitive.
title_short Photodynamic therapy of a mouse glioma: intracranial tumours are resistant while subcutaneous tumours are sensitive.
title_sort photodynamic therapy of a mouse glioma: intracranial tumours are resistant while subcutaneous tumours are sensitive.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971766/
https://www.ncbi.nlm.nih.gov/pubmed/1997101
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AT bonnettr photodynamictherapyofamousegliomaintracranialtumoursareresistantwhilesubcutaneoustumoursaresensitive
AT thomasdg photodynamictherapyofamousegliomaintracranialtumoursareresistantwhilesubcutaneoustumoursaresensitive

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