p53 in colorectal cancer: clinicopathological correlation and prognostic significance.

p53 protein was detected by immunohistochemistry in 42% of 52 colorectal adenocarcinomas. Positive tumours were significantly more frequent in the distal colon, and demonstrated a higher rate of cell proliferation. No correlation was found with tumour grade, Dukes' stage, presence of DNA aneupl...

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Detalles Bibliográficos
Autores principales: Scott, N., Sagar, P., Stewart, J., Blair, G. E., Dixon, M. F., Quirke, P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971769/
https://www.ncbi.nlm.nih.gov/pubmed/1997114
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author Scott, N.
Sagar, P.
Stewart, J.
Blair, G. E.
Dixon, M. F.
Quirke, P.
author_facet Scott, N.
Sagar, P.
Stewart, J.
Blair, G. E.
Dixon, M. F.
Quirke, P.
author_sort Scott, N.
collection PubMed
description p53 protein was detected by immunohistochemistry in 42% of 52 colorectal adenocarcinomas. Positive tumours were significantly more frequent in the distal colon, and demonstrated a higher rate of cell proliferation. No correlation was found with tumour grade, Dukes' stage, presence of DNA aneuploidy or patient survival. The role of p53 in colorectal carcinogenesis is discussed with particular reference to differences between proximal and distal large bowel cancers. IMAGES:
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spelling pubmed-19717692009-09-10 p53 in colorectal cancer: clinicopathological correlation and prognostic significance. Scott, N. Sagar, P. Stewart, J. Blair, G. E. Dixon, M. F. Quirke, P. Br J Cancer Research Article p53 protein was detected by immunohistochemistry in 42% of 52 colorectal adenocarcinomas. Positive tumours were significantly more frequent in the distal colon, and demonstrated a higher rate of cell proliferation. No correlation was found with tumour grade, Dukes' stage, presence of DNA aneuploidy or patient survival. The role of p53 in colorectal carcinogenesis is discussed with particular reference to differences between proximal and distal large bowel cancers. IMAGES: Nature Publishing Group 1991-02 /pmc/articles/PMC1971769/ /pubmed/1997114 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Scott, N.
Sagar, P.
Stewart, J.
Blair, G. E.
Dixon, M. F.
Quirke, P.
p53 in colorectal cancer: clinicopathological correlation and prognostic significance.
title p53 in colorectal cancer: clinicopathological correlation and prognostic significance.
title_full p53 in colorectal cancer: clinicopathological correlation and prognostic significance.
title_fullStr p53 in colorectal cancer: clinicopathological correlation and prognostic significance.
title_full_unstemmed p53 in colorectal cancer: clinicopathological correlation and prognostic significance.
title_short p53 in colorectal cancer: clinicopathological correlation and prognostic significance.
title_sort p53 in colorectal cancer: clinicopathological correlation and prognostic significance.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971769/
https://www.ncbi.nlm.nih.gov/pubmed/1997114
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