Formation of interaction products of carboplatin with DNA in vitro and in cancer patients.

Binding of the cytostatic drug carboplatin to DNA was studied in solution, in RIF-1 and CHO cell lines and in human buccal cells after in vitro or in situ drug exposure. Results were compared with DNA adduction by cisplatin. The rate of binding in solution, determined by atomic absorption spectrosco...

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Detalles Bibliográficos
Autores principales: Terheggen, P. M., Begg, A. C., Emondt, J. Y., Dubbelman, R., Floot, B. G., den Engelse, L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971771/
https://www.ncbi.nlm.nih.gov/pubmed/1997096

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