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Factors associated with childhood cancer in a national cohort study.

Information on 16,193 infants delivered in Great Britain in one week of April, 1970 was collected by midwives at the birth and during the first 7 days of life. Using multiple sources, 33 children developing cancer by 1980 were identified from this cohort, giving an incidence of 2.04 per 1,000 total...

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Autores principales: Golding, J., Paterson, M., Kinlen, L. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1990
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971807/
https://www.ncbi.nlm.nih.gov/pubmed/2386748
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author Golding, J.
Paterson, M.
Kinlen, L. J.
author_facet Golding, J.
Paterson, M.
Kinlen, L. J.
author_sort Golding, J.
collection PubMed
description Information on 16,193 infants delivered in Great Britain in one week of April, 1970 was collected by midwives at the birth and during the first 7 days of life. Using multiple sources, 33 children developing cancer by 1980 were identified from this cohort, giving an incidence of 2.04 per 1,000 total births by the age of 10. Comparisons of these 33 children were made with 99 controls, three for each index case, matched on maternal age, parity and social class. Statistically significant associations were initially found with maternal X-rays and smoking during pregnancy, and the use of analgesics such as pethidine during labour, confirming the findings of retrospective case-control studies. Unexpected statistically significant associations were found with delivery of the child outside term, and drug administration in the first week of life. The latter was found in the absence of an association with neonatal abnormalities in the child and relates mostly to the administration of prophylactic drugs such as vitamin K. Logistic regression involving the whole cohort showed independent statistical associations with maternal smoking (OR 2.5), and drugs to the infant (OR 2.6). After adjusting for these factors no other statistically significant associations were found.
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spelling pubmed-19718072009-09-10 Factors associated with childhood cancer in a national cohort study. Golding, J. Paterson, M. Kinlen, L. J. Br J Cancer Research Article Information on 16,193 infants delivered in Great Britain in one week of April, 1970 was collected by midwives at the birth and during the first 7 days of life. Using multiple sources, 33 children developing cancer by 1980 were identified from this cohort, giving an incidence of 2.04 per 1,000 total births by the age of 10. Comparisons of these 33 children were made with 99 controls, three for each index case, matched on maternal age, parity and social class. Statistically significant associations were initially found with maternal X-rays and smoking during pregnancy, and the use of analgesics such as pethidine during labour, confirming the findings of retrospective case-control studies. Unexpected statistically significant associations were found with delivery of the child outside term, and drug administration in the first week of life. The latter was found in the absence of an association with neonatal abnormalities in the child and relates mostly to the administration of prophylactic drugs such as vitamin K. Logistic regression involving the whole cohort showed independent statistical associations with maternal smoking (OR 2.5), and drugs to the infant (OR 2.6). After adjusting for these factors no other statistically significant associations were found. Nature Publishing Group 1990-08 /pmc/articles/PMC1971807/ /pubmed/2386748 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Golding, J.
Paterson, M.
Kinlen, L. J.
Factors associated with childhood cancer in a national cohort study.
title Factors associated with childhood cancer in a national cohort study.
title_full Factors associated with childhood cancer in a national cohort study.
title_fullStr Factors associated with childhood cancer in a national cohort study.
title_full_unstemmed Factors associated with childhood cancer in a national cohort study.
title_short Factors associated with childhood cancer in a national cohort study.
title_sort factors associated with childhood cancer in a national cohort study.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971807/
https://www.ncbi.nlm.nih.gov/pubmed/2386748
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