Alfacalcidol is a nontoxic, effective treatment of follicular small-cleaved cell lymphoma.

Thirty-four patients with progressive low grade non-Hodgkin's lymphoma were treated with 1 microgram oral alfacalcidol daily. Complete response was seen in four patients and a partial response in four patients with an overall response rate of 24%. Median duration of response was 14 months. Dise...

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Autores principales: Raina, V., Cunningham, D., Gilchrist, N., Soukop, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971849/
https://www.ncbi.nlm.nih.gov/pubmed/2003990
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author Raina, V.
Cunningham, D.
Gilchrist, N.
Soukop, M.
author_facet Raina, V.
Cunningham, D.
Gilchrist, N.
Soukop, M.
author_sort Raina, V.
collection PubMed
description Thirty-four patients with progressive low grade non-Hodgkin's lymphoma were treated with 1 microgram oral alfacalcidol daily. Complete response was seen in four patients and a partial response in four patients with an overall response rate of 24%. Median duration of response was 14 months. Disease stabilised in ten other patients (29%) and 16 patients (47%) had tumour progression. In the sub-group of patients with follicular, small-cleaved cell-lymphoma the overall response to treatment was 29%. Apart from one patient who had a mild transitory elevation of serum calcium there was no recorded toxicity from alfacidol. These results indicate that alfacalcidol has significant antitumour activity in patients with low grade non-Hodgkin's lymphoma of the follicular, small-cleaved cell type. IMAGES:
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spelling pubmed-19718492009-09-10 Alfacalcidol is a nontoxic, effective treatment of follicular small-cleaved cell lymphoma. Raina, V. Cunningham, D. Gilchrist, N. Soukop, M. Br J Cancer Research Article Thirty-four patients with progressive low grade non-Hodgkin's lymphoma were treated with 1 microgram oral alfacalcidol daily. Complete response was seen in four patients and a partial response in four patients with an overall response rate of 24%. Median duration of response was 14 months. Disease stabilised in ten other patients (29%) and 16 patients (47%) had tumour progression. In the sub-group of patients with follicular, small-cleaved cell-lymphoma the overall response to treatment was 29%. Apart from one patient who had a mild transitory elevation of serum calcium there was no recorded toxicity from alfacidol. These results indicate that alfacalcidol has significant antitumour activity in patients with low grade non-Hodgkin's lymphoma of the follicular, small-cleaved cell type. IMAGES: Nature Publishing Group 1991-03 /pmc/articles/PMC1971849/ /pubmed/2003990 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Raina, V.
Cunningham, D.
Gilchrist, N.
Soukop, M.
Alfacalcidol is a nontoxic, effective treatment of follicular small-cleaved cell lymphoma.
title Alfacalcidol is a nontoxic, effective treatment of follicular small-cleaved cell lymphoma.
title_full Alfacalcidol is a nontoxic, effective treatment of follicular small-cleaved cell lymphoma.
title_fullStr Alfacalcidol is a nontoxic, effective treatment of follicular small-cleaved cell lymphoma.
title_full_unstemmed Alfacalcidol is a nontoxic, effective treatment of follicular small-cleaved cell lymphoma.
title_short Alfacalcidol is a nontoxic, effective treatment of follicular small-cleaved cell lymphoma.
title_sort alfacalcidol is a nontoxic, effective treatment of follicular small-cleaved cell lymphoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971849/
https://www.ncbi.nlm.nih.gov/pubmed/2003990
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AT gilchristn alfacalcidolisanontoxiceffectivetreatmentoffollicularsmallcleavedcelllymphoma
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