Cargando…
SR 4233 cytotoxicity and metabolism in DNA repair-competent and repair-deficient cell cultures.
In order to understand in more detail the mechanism underlying the preferential hypoxic cytotoxicity of the benzotriazine N-oxide SR 4233, we have compared the hypoxic cytotoxicity of this drug to the rates of hypoxic metabolism in both DNA double strand break repair-competent and repair-deficient c...
Autores principales: | Biedermann, K. A., Wang, J., Graham, R. P., Brown, J. M. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1991
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971850/ https://www.ncbi.nlm.nih.gov/pubmed/2003976 |
Ejemplares similares
-
Metabolism of the bioreductive cytotoxin SR 4233 by tumour cells: enzymatic studies.
por: Wang, J., et al.
Publicado: (1993) -
Enhancement of the cytotoxicity of SR 4233 to normal and malignant tissues by hypoxic breathing.
por: Minchinton, A. I., et al.
Publicado: (1992) -
The effect of pH on the aerobic and hypoxic cytotoxicity of SR4233 in HT-29 cells.
por: Skarsgard, L. D., et al.
Publicado: (1993) -
SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours.
por: Brown, J. M.
Publicado: (1993) -
Molecular mechanisms of SR 4233-induced hepatocyte toxicity under aerobic versus hypoxic conditions.
por: Silva, J. M., et al.
Publicado: (1993)