c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes.

The c-erbB-2 gene is overexpressed in about 20% of human breast cancers. Four hundred and eighty-three cases previously examined by immunohistochemical staining for c-erbB-2 expression were analysed to assess the risk associated with the elevated protein expression. Oncoprotein expression was correl...

Descripción completa

Detalles Bibliográficos
Autores principales: Gullick, W. J., Love, S. B., Wright, C., Barnes, D. M., Gusterson, B., Harris, A. L., Altman, D. G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971853/
https://www.ncbi.nlm.nih.gov/pubmed/1672253
_version_ 1782134999051403264
author Gullick, W. J.
Love, S. B.
Wright, C.
Barnes, D. M.
Gusterson, B.
Harris, A. L.
Altman, D. G.
author_facet Gullick, W. J.
Love, S. B.
Wright, C.
Barnes, D. M.
Gusterson, B.
Harris, A. L.
Altman, D. G.
author_sort Gullick, W. J.
collection PubMed
description The c-erbB-2 gene is overexpressed in about 20% of human breast cancers. Four hundred and eighty-three cases previously examined by immunohistochemical staining for c-erbB-2 expression were analysed to assess the risk associated with the elevated protein expression. Oncoprotein expression was correlated with increasing tumour grade but not with oestrogen receptor status, nodal involvement, tumour size or age. There was an increased risk of relapse and death associated with c-erbB-2 expression irrespective of nodal involvement. This marker thus appears to be a significant prognostic factor in the early as well as the late stages of breast cancer.
format Text
id pubmed-1971853
institution National Center for Biotechnology Information
language English
publishDate 1991
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-19718532009-09-10 c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes. Gullick, W. J. Love, S. B. Wright, C. Barnes, D. M. Gusterson, B. Harris, A. L. Altman, D. G. Br J Cancer Research Article The c-erbB-2 gene is overexpressed in about 20% of human breast cancers. Four hundred and eighty-three cases previously examined by immunohistochemical staining for c-erbB-2 expression were analysed to assess the risk associated with the elevated protein expression. Oncoprotein expression was correlated with increasing tumour grade but not with oestrogen receptor status, nodal involvement, tumour size or age. There was an increased risk of relapse and death associated with c-erbB-2 expression irrespective of nodal involvement. This marker thus appears to be a significant prognostic factor in the early as well as the late stages of breast cancer. Nature Publishing Group 1991-03 /pmc/articles/PMC1971853/ /pubmed/1672253 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Gullick, W. J.
Love, S. B.
Wright, C.
Barnes, D. M.
Gusterson, B.
Harris, A. L.
Altman, D. G.
c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes.
title c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes.
title_full c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes.
title_fullStr c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes.
title_full_unstemmed c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes.
title_short c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes.
title_sort c-erbb-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971853/
https://www.ncbi.nlm.nih.gov/pubmed/1672253
work_keys_str_mv AT gullickwj cerbb2proteinoverexpressioninbreastcancerisariskfactorinpatientswithinvolvedanduninvolvedlymphnodes
AT lovesb cerbb2proteinoverexpressioninbreastcancerisariskfactorinpatientswithinvolvedanduninvolvedlymphnodes
AT wrightc cerbb2proteinoverexpressioninbreastcancerisariskfactorinpatientswithinvolvedanduninvolvedlymphnodes
AT barnesdm cerbb2proteinoverexpressioninbreastcancerisariskfactorinpatientswithinvolvedanduninvolvedlymphnodes
AT gustersonb cerbb2proteinoverexpressioninbreastcancerisariskfactorinpatientswithinvolvedanduninvolvedlymphnodes
AT harrisal cerbb2proteinoverexpressioninbreastcancerisariskfactorinpatientswithinvolvedanduninvolvedlymphnodes
AT altmandg cerbb2proteinoverexpressioninbreastcancerisariskfactorinpatientswithinvolvedanduninvolvedlymphnodes

Ejemplares similares