The relationship between c-erbB-2 expression, S-phase fraction and prognosis in breast cancer.

The relationship between c-erbB-2 gene expression (assessed immunohistochemically), S-phase fraction (SPF) and prognosis has been analysed in 172 women with primary breast cancer. c-erbB-2 staining was independent of age, tumour size, number of nodes involved, tumour grade and DNA ploidy, but was mo...

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Autores principales: O'Reilly, S. M., Barnes, D. M., Camplejohn, R. S., Bartkova, J., Gregory, W. M., Richards, M. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971877/
https://www.ncbi.nlm.nih.gov/pubmed/1672255
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author O'Reilly, S. M.
Barnes, D. M.
Camplejohn, R. S.
Bartkova, J.
Gregory, W. M.
Richards, M. A.
author_facet O'Reilly, S. M.
Barnes, D. M.
Camplejohn, R. S.
Bartkova, J.
Gregory, W. M.
Richards, M. A.
author_sort O'Reilly, S. M.
collection PubMed
description The relationship between c-erbB-2 gene expression (assessed immunohistochemically), S-phase fraction (SPF) and prognosis has been analysed in 172 women with primary breast cancer. c-erbB-2 staining was independent of age, tumour size, number of nodes involved, tumour grade and DNA ploidy, but was more common in oestrogen receptor (ER) negative tumours (P = 0.02) and progesterone receptor (PgR) negative tumours (P = 0.03). A weak correlation between c-erbB-2 staining and SPF was observed (r = 0.18). Amongst women with node negative disease, SPF was significantly related to relapse free survival (RFS, P = 0.04) while c-erbB-2 staining was not (P = 0.2). In contrast, both SPF (P = 0.002) and c-erbB-2 staining (P = 0.016) provided significant prognostic information on RFS for women with node positive disease. Multivariate analysis showed that c-erbB-2 staining and SPF gave independent information on RFS for women with node positive disease.
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spelling pubmed-19718772009-09-10 The relationship between c-erbB-2 expression, S-phase fraction and prognosis in breast cancer. O'Reilly, S. M. Barnes, D. M. Camplejohn, R. S. Bartkova, J. Gregory, W. M. Richards, M. A. Br J Cancer Research Article The relationship between c-erbB-2 gene expression (assessed immunohistochemically), S-phase fraction (SPF) and prognosis has been analysed in 172 women with primary breast cancer. c-erbB-2 staining was independent of age, tumour size, number of nodes involved, tumour grade and DNA ploidy, but was more common in oestrogen receptor (ER) negative tumours (P = 0.02) and progesterone receptor (PgR) negative tumours (P = 0.03). A weak correlation between c-erbB-2 staining and SPF was observed (r = 0.18). Amongst women with node negative disease, SPF was significantly related to relapse free survival (RFS, P = 0.04) while c-erbB-2 staining was not (P = 0.2). In contrast, both SPF (P = 0.002) and c-erbB-2 staining (P = 0.016) provided significant prognostic information on RFS for women with node positive disease. Multivariate analysis showed that c-erbB-2 staining and SPF gave independent information on RFS for women with node positive disease. Nature Publishing Group 1991-03 /pmc/articles/PMC1971877/ /pubmed/1672255 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
O'Reilly, S. M.
Barnes, D. M.
Camplejohn, R. S.
Bartkova, J.
Gregory, W. M.
Richards, M. A.
The relationship between c-erbB-2 expression, S-phase fraction and prognosis in breast cancer.
title The relationship between c-erbB-2 expression, S-phase fraction and prognosis in breast cancer.
title_full The relationship between c-erbB-2 expression, S-phase fraction and prognosis in breast cancer.
title_fullStr The relationship between c-erbB-2 expression, S-phase fraction and prognosis in breast cancer.
title_full_unstemmed The relationship between c-erbB-2 expression, S-phase fraction and prognosis in breast cancer.
title_short The relationship between c-erbB-2 expression, S-phase fraction and prognosis in breast cancer.
title_sort relationship between c-erbb-2 expression, s-phase fraction and prognosis in breast cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971877/
https://www.ncbi.nlm.nih.gov/pubmed/1672255
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