Epidermal growth factor receptors in intracranial and breast tumours: their clinical significance.

A method to determine the binding of epidermal growth factor (EGF) to the particulate fraction of the cell has been established and evaluated using rat liver, human placenta, and tumours of human breast and brain. Little EGF receptor (EGFR) activity was detected in normal or benign tumour tissues ex...

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Autores principales: Hawkins, R. A., Killen, E., Whittle, I. R., Jack, W. J., Chetty, U., Prescott, R. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1972349/
https://www.ncbi.nlm.nih.gov/pubmed/2021539
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author Hawkins, R. A.
Killen, E.
Whittle, I. R.
Jack, W. J.
Chetty, U.
Prescott, R. J.
author_facet Hawkins, R. A.
Killen, E.
Whittle, I. R.
Jack, W. J.
Chetty, U.
Prescott, R. J.
author_sort Hawkins, R. A.
collection PubMed
description A method to determine the binding of epidermal growth factor (EGF) to the particulate fraction of the cell has been established and evaluated using rat liver, human placenta, and tumours of human breast and brain. Little EGF receptor (EGFR) activity was detected in normal or benign tumour tissues except for meningioma (positive in 95% samples), but EGFR were present in 43% of 131 breast tumours and 75% of 55 primary cerebral tumours. Despite the strong inverse correlation between EGFR activity and oestrogen receptors in breast tumours and a tendency for high levels of EGFR activity to be associated with glioblastoma multiforme, analysis showed that EGFR was of little prognostic significance in patients with tumours of either breast or brain.
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spelling pubmed-19723492009-09-10 Epidermal growth factor receptors in intracranial and breast tumours: their clinical significance. Hawkins, R. A. Killen, E. Whittle, I. R. Jack, W. J. Chetty, U. Prescott, R. J. Br J Cancer Research Article A method to determine the binding of epidermal growth factor (EGF) to the particulate fraction of the cell has been established and evaluated using rat liver, human placenta, and tumours of human breast and brain. Little EGF receptor (EGFR) activity was detected in normal or benign tumour tissues except for meningioma (positive in 95% samples), but EGFR were present in 43% of 131 breast tumours and 75% of 55 primary cerebral tumours. Despite the strong inverse correlation between EGFR activity and oestrogen receptors in breast tumours and a tendency for high levels of EGFR activity to be associated with glioblastoma multiforme, analysis showed that EGFR was of little prognostic significance in patients with tumours of either breast or brain. Nature Publishing Group 1991-04 /pmc/articles/PMC1972349/ /pubmed/2021539 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Hawkins, R. A.
Killen, E.
Whittle, I. R.
Jack, W. J.
Chetty, U.
Prescott, R. J.
Epidermal growth factor receptors in intracranial and breast tumours: their clinical significance.
title Epidermal growth factor receptors in intracranial and breast tumours: their clinical significance.
title_full Epidermal growth factor receptors in intracranial and breast tumours: their clinical significance.
title_fullStr Epidermal growth factor receptors in intracranial and breast tumours: their clinical significance.
title_full_unstemmed Epidermal growth factor receptors in intracranial and breast tumours: their clinical significance.
title_short Epidermal growth factor receptors in intracranial and breast tumours: their clinical significance.
title_sort epidermal growth factor receptors in intracranial and breast tumours: their clinical significance.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1972349/
https://www.ncbi.nlm.nih.gov/pubmed/2021539
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