Application of boronated anti-CEA immunoliposome to tumour cell growth inhibition in in vitro boron neutron capture therapy model.

An immunoliposome containing a 10B-compound has been examined as a selective drug delivery system in boron neutron-capture therapy. Liposomes, conjugated with monoclonal antibodies specific for carcinoembryonic antigen (CEA) were shown to bind selectively to cells bearing CEA on their surface. The i...

Descripción completa

Detalles Bibliográficos
Autores principales: Yanagië, H., Tomita, T., Kobayashi, H., Fujii, Y., Takahashi, T., Hasumi, K., Nariuchi, H., Sekiguchi, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1972354/
https://www.ncbi.nlm.nih.gov/pubmed/2021537
_version_ 1782135010900312064
author Yanagië, H.
Tomita, T.
Kobayashi, H.
Fujii, Y.
Takahashi, T.
Hasumi, K.
Nariuchi, H.
Sekiguchi, M.
author_facet Yanagië, H.
Tomita, T.
Kobayashi, H.
Fujii, Y.
Takahashi, T.
Hasumi, K.
Nariuchi, H.
Sekiguchi, M.
author_sort Yanagië, H.
collection PubMed
description An immunoliposome containing a 10B-compound has been examined as a selective drug delivery system in boron neutron-capture therapy. Liposomes, conjugated with monoclonal antibodies specific for carcinoembryonic antigen (CEA) were shown to bind selectively to cells bearing CEA on their surface. The immunoliposomes attached to tumour cells suppressed growth in vitro upon thermal neutron irradiation and suppression was dependent upon the concentration of the 10B-compound in the liposomes and on the density of antibody conjugated to the liposomes. The results suggest that immunoliposomes containing the 10B-compound could act as a selective and efficient carrier of 10B atoms to target tumour cells in boron neutron-capture therapy. IMAGES:
format Text
id pubmed-1972354
institution National Center for Biotechnology Information
language English
publishDate 1991
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-19723542009-09-10 Application of boronated anti-CEA immunoliposome to tumour cell growth inhibition in in vitro boron neutron capture therapy model. Yanagië, H. Tomita, T. Kobayashi, H. Fujii, Y. Takahashi, T. Hasumi, K. Nariuchi, H. Sekiguchi, M. Br J Cancer Research Article An immunoliposome containing a 10B-compound has been examined as a selective drug delivery system in boron neutron-capture therapy. Liposomes, conjugated with monoclonal antibodies specific for carcinoembryonic antigen (CEA) were shown to bind selectively to cells bearing CEA on their surface. The immunoliposomes attached to tumour cells suppressed growth in vitro upon thermal neutron irradiation and suppression was dependent upon the concentration of the 10B-compound in the liposomes and on the density of antibody conjugated to the liposomes. The results suggest that immunoliposomes containing the 10B-compound could act as a selective and efficient carrier of 10B atoms to target tumour cells in boron neutron-capture therapy. IMAGES: Nature Publishing Group 1991-04 /pmc/articles/PMC1972354/ /pubmed/2021537 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Yanagië, H.
Tomita, T.
Kobayashi, H.
Fujii, Y.
Takahashi, T.
Hasumi, K.
Nariuchi, H.
Sekiguchi, M.
Application of boronated anti-CEA immunoliposome to tumour cell growth inhibition in in vitro boron neutron capture therapy model.
title Application of boronated anti-CEA immunoliposome to tumour cell growth inhibition in in vitro boron neutron capture therapy model.
title_full Application of boronated anti-CEA immunoliposome to tumour cell growth inhibition in in vitro boron neutron capture therapy model.
title_fullStr Application of boronated anti-CEA immunoliposome to tumour cell growth inhibition in in vitro boron neutron capture therapy model.
title_full_unstemmed Application of boronated anti-CEA immunoliposome to tumour cell growth inhibition in in vitro boron neutron capture therapy model.
title_short Application of boronated anti-CEA immunoliposome to tumour cell growth inhibition in in vitro boron neutron capture therapy model.
title_sort application of boronated anti-cea immunoliposome to tumour cell growth inhibition in in vitro boron neutron capture therapy model.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1972354/
https://www.ncbi.nlm.nih.gov/pubmed/2021537
work_keys_str_mv AT yanagieh applicationofboronatedanticeaimmunoliposometotumourcellgrowthinhibitionininvitroboronneutroncapturetherapymodel
AT tomitat applicationofboronatedanticeaimmunoliposometotumourcellgrowthinhibitionininvitroboronneutroncapturetherapymodel
AT kobayashih applicationofboronatedanticeaimmunoliposometotumourcellgrowthinhibitionininvitroboronneutroncapturetherapymodel
AT fujiiy applicationofboronatedanticeaimmunoliposometotumourcellgrowthinhibitionininvitroboronneutroncapturetherapymodel
AT takahashit applicationofboronatedanticeaimmunoliposometotumourcellgrowthinhibitionininvitroboronneutroncapturetherapymodel
AT hasumik applicationofboronatedanticeaimmunoliposometotumourcellgrowthinhibitionininvitroboronneutroncapturetherapymodel
AT nariuchih applicationofboronatedanticeaimmunoliposometotumourcellgrowthinhibitionininvitroboronneutroncapturetherapymodel
AT sekiguchim applicationofboronatedanticeaimmunoliposometotumourcellgrowthinhibitionininvitroboronneutroncapturetherapymodel

Ejemplares similares