Metallothionein levels in ovarian tumours before and after chemotherapy.

The metallothionein content of ovarian tumours is considerably higher than that found in normal ovaries (greater than 100-fold differences in mean values, P less than 0.001). There was no difference between the metallothionein content of tumours from patients who had completed chemotherapy, usually...

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Autores principales: Murphy, D., McGown, A. T., Crowther, D., Mander, A., Fox, B. W.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1972381/
https://www.ncbi.nlm.nih.gov/pubmed/2039697
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author Murphy, D.
McGown, A. T.
Crowther, D.
Mander, A.
Fox, B. W.
author_facet Murphy, D.
McGown, A. T.
Crowther, D.
Mander, A.
Fox, B. W.
author_sort Murphy, D.
collection PubMed
description The metallothionein content of ovarian tumours is considerably higher than that found in normal ovaries (greater than 100-fold differences in mean values, P less than 0.001). There was no difference between the metallothionein content of tumours from patients who had completed chemotherapy, usually with a regimen containing a platinum drug, and tumours from untreated patients. Similarly, the level of metallothionein was not influenced by response to therapy, age, stage, histology, or tumour cell differentiation state. These data do not support the hypothesis that metallothionein content is a major determinant of tumour sensitivity in ovarian cancer.
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spelling pubmed-19723812009-09-10 Metallothionein levels in ovarian tumours before and after chemotherapy. Murphy, D. McGown, A. T. Crowther, D. Mander, A. Fox, B. W. Br J Cancer Research Article The metallothionein content of ovarian tumours is considerably higher than that found in normal ovaries (greater than 100-fold differences in mean values, P less than 0.001). There was no difference between the metallothionein content of tumours from patients who had completed chemotherapy, usually with a regimen containing a platinum drug, and tumours from untreated patients. Similarly, the level of metallothionein was not influenced by response to therapy, age, stage, histology, or tumour cell differentiation state. These data do not support the hypothesis that metallothionein content is a major determinant of tumour sensitivity in ovarian cancer. Nature Publishing Group 1991-05 /pmc/articles/PMC1972381/ /pubmed/2039697 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Murphy, D.
McGown, A. T.
Crowther, D.
Mander, A.
Fox, B. W.
Metallothionein levels in ovarian tumours before and after chemotherapy.
title Metallothionein levels in ovarian tumours before and after chemotherapy.
title_full Metallothionein levels in ovarian tumours before and after chemotherapy.
title_fullStr Metallothionein levels in ovarian tumours before and after chemotherapy.
title_full_unstemmed Metallothionein levels in ovarian tumours before and after chemotherapy.
title_short Metallothionein levels in ovarian tumours before and after chemotherapy.
title_sort metallothionein levels in ovarian tumours before and after chemotherapy.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1972381/
https://www.ncbi.nlm.nih.gov/pubmed/2039697
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AT mcgownat metallothioneinlevelsinovariantumoursbeforeandafterchemotherapy
AT crowtherd metallothioneinlevelsinovariantumoursbeforeandafterchemotherapy
AT mandera metallothioneinlevelsinovariantumoursbeforeandafterchemotherapy
AT foxbw metallothioneinlevelsinovariantumoursbeforeandafterchemotherapy

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