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Lipogenesis in tumour and host tissues in mice bearing colonic adenocarcinomas.
Although animals bearing the MAC16 colon adenocarcinoma showed progressive weight loss, the average food consumption (15.1 +/- 0.6 Kcal day-1) did not differ from non tumour-bearing controls (15.3 +/- 0.3 Kcal day-1), while animals bearing a related colon adenocarcinoma, MAC13, which had no effect o...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1991
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1972399/ https://www.ncbi.nlm.nih.gov/pubmed/1674876 |
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author | Mulligan, H. D. Tisdale, M. J. |
author_facet | Mulligan, H. D. Tisdale, M. J. |
author_sort | Mulligan, H. D. |
collection | PubMed |
description | Although animals bearing the MAC16 colon adenocarcinoma showed progressive weight loss, the average food consumption (15.1 +/- 0.6 Kcal day-1) did not differ from non tumour-bearing controls (15.3 +/- 0.3 Kcal day-1), while animals bearing a related colon adenocarcinoma, MAC13, which had no effect on body weight had a significantly (P less than 0.01) elevated food intake (16.4 +/- 0.3 Kcal day-1) above controls. Weight loss in animals bearing the MAC16 tumour was associated with a significant reduction in the percentage contribution of the kidneys, colon and epididymal fat pads to the total body weight. Although loss of body fat occurred only in the MAC16 model, both tumours were capable of synthesising lipids from glucose both in vitro and in vivo at the same rate. In addition both tumours increased the rate of lipogenesis from glucose in kidney, liver and epididymal fat pads of the host. Lipogenesis from glucose would be expected to result in a loss of utilisable carbohydrate energy and thus would be expected to increase the overall energy requirements in the tumour-bearing state leading to catabolism of host body tissues if the energy intake is not increased. |
format | Text |
id | pubmed-1972399 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1991 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-19723992009-09-10 Lipogenesis in tumour and host tissues in mice bearing colonic adenocarcinomas. Mulligan, H. D. Tisdale, M. J. Br J Cancer Research Article Although animals bearing the MAC16 colon adenocarcinoma showed progressive weight loss, the average food consumption (15.1 +/- 0.6 Kcal day-1) did not differ from non tumour-bearing controls (15.3 +/- 0.3 Kcal day-1), while animals bearing a related colon adenocarcinoma, MAC13, which had no effect on body weight had a significantly (P less than 0.01) elevated food intake (16.4 +/- 0.3 Kcal day-1) above controls. Weight loss in animals bearing the MAC16 tumour was associated with a significant reduction in the percentage contribution of the kidneys, colon and epididymal fat pads to the total body weight. Although loss of body fat occurred only in the MAC16 model, both tumours were capable of synthesising lipids from glucose both in vitro and in vivo at the same rate. In addition both tumours increased the rate of lipogenesis from glucose in kidney, liver and epididymal fat pads of the host. Lipogenesis from glucose would be expected to result in a loss of utilisable carbohydrate energy and thus would be expected to increase the overall energy requirements in the tumour-bearing state leading to catabolism of host body tissues if the energy intake is not increased. Nature Publishing Group 1991-05 /pmc/articles/PMC1972399/ /pubmed/1674876 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Mulligan, H. D. Tisdale, M. J. Lipogenesis in tumour and host tissues in mice bearing colonic adenocarcinomas. |
title | Lipogenesis in tumour and host tissues in mice bearing colonic adenocarcinomas. |
title_full | Lipogenesis in tumour and host tissues in mice bearing colonic adenocarcinomas. |
title_fullStr | Lipogenesis in tumour and host tissues in mice bearing colonic adenocarcinomas. |
title_full_unstemmed | Lipogenesis in tumour and host tissues in mice bearing colonic adenocarcinomas. |
title_short | Lipogenesis in tumour and host tissues in mice bearing colonic adenocarcinomas. |
title_sort | lipogenesis in tumour and host tissues in mice bearing colonic adenocarcinomas. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1972399/ https://www.ncbi.nlm.nih.gov/pubmed/1674876 |
work_keys_str_mv | AT mulliganhd lipogenesisintumourandhosttissuesinmicebearingcolonicadenocarcinomas AT tisdalemj lipogenesisintumourandhosttissuesinmicebearingcolonicadenocarcinomas |