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Intraperitoneal cytostatics impair healing of experimental intestinal anastomoses.

We investigated the effect of two doses of cytostatics, administered intraperitoneally during 5 consecutive days, on the healing of ileal and colonic anastomoses constructed on the third day. The cytostatics regimen consisted of a combination of 5-fluorouracil, bleomycin and cisplatin at 10, 2 and 0...

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Autores principales: de Roy van Zuidewijn, D. B., Hendriks, T., Wobbes, T., de Boer, H. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1972524/
https://www.ncbi.nlm.nih.gov/pubmed/1712623
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author de Roy van Zuidewijn, D. B.
Hendriks, T.
Wobbes, T.
de Boer, H. H.
author_facet de Roy van Zuidewijn, D. B.
Hendriks, T.
Wobbes, T.
de Boer, H. H.
author_sort de Roy van Zuidewijn, D. B.
collection PubMed
description We investigated the effect of two doses of cytostatics, administered intraperitoneally during 5 consecutive days, on the healing of ileal and colonic anastomoses constructed on the third day. The cytostatics regimen consisted of a combination of 5-fluorouracil, bleomycin and cisplatin at 10, 2 and 0.35 mg kg-1d-1, respectively, or at twice higher doses. The lower dose was similar to that given intravenously in previous experiments. Rats were sacrificed 3 or 7 days after operation. No effects of cytostatics were observed after 3 days, neither on anastomotic bursting pressure nor on hydroxyproline concentration (microgram/mg dry weight) or content (microgram cm-1). Profound effects were seen at 7 days. In the high dose group, bursting pressures in both anastomoses were greatly reduced with respect to the control group. Concurrently, collagen synthesis was severely impaired, as indicated by sustained decreased hydroxyproline concentrations and content. The lower dose of cytostatics showed essentially similar effects on hydroxyproline parameters, but affected anastomotic strength less dramatically. The data indicate that, while intraperitoneal chemotherapy may show less detrimental systemic toxicity and thus allow higher doses, its application as an adjunct to gastrointestinal surgery may be limited because of its severe effects on anastomotic repair.
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spelling pubmed-19725242009-09-10 Intraperitoneal cytostatics impair healing of experimental intestinal anastomoses. de Roy van Zuidewijn, D. B. Hendriks, T. Wobbes, T. de Boer, H. H. Br J Cancer Research Article We investigated the effect of two doses of cytostatics, administered intraperitoneally during 5 consecutive days, on the healing of ileal and colonic anastomoses constructed on the third day. The cytostatics regimen consisted of a combination of 5-fluorouracil, bleomycin and cisplatin at 10, 2 and 0.35 mg kg-1d-1, respectively, or at twice higher doses. The lower dose was similar to that given intravenously in previous experiments. Rats were sacrificed 3 or 7 days after operation. No effects of cytostatics were observed after 3 days, neither on anastomotic bursting pressure nor on hydroxyproline concentration (microgram/mg dry weight) or content (microgram cm-1). Profound effects were seen at 7 days. In the high dose group, bursting pressures in both anastomoses were greatly reduced with respect to the control group. Concurrently, collagen synthesis was severely impaired, as indicated by sustained decreased hydroxyproline concentrations and content. The lower dose of cytostatics showed essentially similar effects on hydroxyproline parameters, but affected anastomotic strength less dramatically. The data indicate that, while intraperitoneal chemotherapy may show less detrimental systemic toxicity and thus allow higher doses, its application as an adjunct to gastrointestinal surgery may be limited because of its severe effects on anastomotic repair. Nature Publishing Group 1991-06 /pmc/articles/PMC1972524/ /pubmed/1712623 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
de Roy van Zuidewijn, D. B.
Hendriks, T.
Wobbes, T.
de Boer, H. H.
Intraperitoneal cytostatics impair healing of experimental intestinal anastomoses.
title Intraperitoneal cytostatics impair healing of experimental intestinal anastomoses.
title_full Intraperitoneal cytostatics impair healing of experimental intestinal anastomoses.
title_fullStr Intraperitoneal cytostatics impair healing of experimental intestinal anastomoses.
title_full_unstemmed Intraperitoneal cytostatics impair healing of experimental intestinal anastomoses.
title_short Intraperitoneal cytostatics impair healing of experimental intestinal anastomoses.
title_sort intraperitoneal cytostatics impair healing of experimental intestinal anastomoses.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1972524/
https://www.ncbi.nlm.nih.gov/pubmed/1712623
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