Monitoring therapeutic response to tamoxifen in NMU-induced rat mammary tumours by 31P MRS.

Tamoxifen injections were given once a week for 4 weeks to 19 rats bearing N-methyl-N-nitrosourea (NMU)-induced mammary carcinomas. NMR spectra were collected on days 2, 7, 14, 21 and 28. Only 42% of the tumours responded to the tamoxifen in that they regressed significantly; another 21% did not cha...

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Autores principales: Baluch, S., Midwood, C. J., Griffiths, J. R., Stubbs, M., Coombes, R. C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1972538/
https://www.ncbi.nlm.nih.gov/pubmed/2069847
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author Baluch, S.
Midwood, C. J.
Griffiths, J. R.
Stubbs, M.
Coombes, R. C.
author_facet Baluch, S.
Midwood, C. J.
Griffiths, J. R.
Stubbs, M.
Coombes, R. C.
author_sort Baluch, S.
collection PubMed
description Tamoxifen injections were given once a week for 4 weeks to 19 rats bearing N-methyl-N-nitrosourea (NMU)-induced mammary carcinomas. NMR spectra were collected on days 2, 7, 14, 21 and 28. Only 42% of the tumours responded to the tamoxifen in that they regressed significantly; another 21% did not change in size and 37% grew significantly. In the ones that did subsequently regress there were significant changes in the NTP/Pi ratio as early as 2 days after treatment, before any detectable change in volume was recorded, and continuing up to 21 days. The significance of these findings and the possible mechanisms underlying the changes are discussed.
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spelling pubmed-19725382009-09-10 Monitoring therapeutic response to tamoxifen in NMU-induced rat mammary tumours by 31P MRS. Baluch, S. Midwood, C. J. Griffiths, J. R. Stubbs, M. Coombes, R. C. Br J Cancer Research Article Tamoxifen injections were given once a week for 4 weeks to 19 rats bearing N-methyl-N-nitrosourea (NMU)-induced mammary carcinomas. NMR spectra were collected on days 2, 7, 14, 21 and 28. Only 42% of the tumours responded to the tamoxifen in that they regressed significantly; another 21% did not change in size and 37% grew significantly. In the ones that did subsequently regress there were significant changes in the NTP/Pi ratio as early as 2 days after treatment, before any detectable change in volume was recorded, and continuing up to 21 days. The significance of these findings and the possible mechanisms underlying the changes are discussed. Nature Publishing Group 1991-06 /pmc/articles/PMC1972538/ /pubmed/2069847 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Baluch, S.
Midwood, C. J.
Griffiths, J. R.
Stubbs, M.
Coombes, R. C.
Monitoring therapeutic response to tamoxifen in NMU-induced rat mammary tumours by 31P MRS.
title Monitoring therapeutic response to tamoxifen in NMU-induced rat mammary tumours by 31P MRS.
title_full Monitoring therapeutic response to tamoxifen in NMU-induced rat mammary tumours by 31P MRS.
title_fullStr Monitoring therapeutic response to tamoxifen in NMU-induced rat mammary tumours by 31P MRS.
title_full_unstemmed Monitoring therapeutic response to tamoxifen in NMU-induced rat mammary tumours by 31P MRS.
title_short Monitoring therapeutic response to tamoxifen in NMU-induced rat mammary tumours by 31P MRS.
title_sort monitoring therapeutic response to tamoxifen in nmu-induced rat mammary tumours by 31p mrs.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1972538/
https://www.ncbi.nlm.nih.gov/pubmed/2069847
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