Cancer risk in second degree relatives of children with soft tissue sarcoma.

The risk of cancer in the second degree relatives of a population-based series of children with soft tissue sarcoma was studied in relation to (i) various characteristics in these relatives, (ii) certain clinical features in the index children previously identified as risk factors for cancer in thei...

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Autores principales: Hartley, A. L., Birch, J. M., Teare, M. D., Blair, V., Kelsey, A. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1972540/
https://www.ncbi.nlm.nih.gov/pubmed/2069851
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author Hartley, A. L.
Birch, J. M.
Teare, M. D.
Blair, V.
Kelsey, A. M.
author_facet Hartley, A. L.
Birch, J. M.
Teare, M. D.
Blair, V.
Kelsey, A. M.
author_sort Hartley, A. L.
collection PubMed
description The risk of cancer in the second degree relatives of a population-based series of children with soft tissue sarcoma was studied in relation to (i) various characteristics in these relatives, (ii) certain clinical features in the index children previously identified as risk factors for cancer in their first degree relatives. Overall there was a non-significant deficit of cancers in the second degree relatives (RR = 0.88) and cancer risk was unrelated to type or site of cancer, type of relative, or to risk factors in the index case. The findings indicate that although the families investigated may include a proportion with the Li-Fraumeni cancer family syndrome, the increased cancer risk already reported in the first degree relatives does not extent to second degree relatives in general.
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spelling pubmed-19725402009-09-10 Cancer risk in second degree relatives of children with soft tissue sarcoma. Hartley, A. L. Birch, J. M. Teare, M. D. Blair, V. Kelsey, A. M. Br J Cancer Research Article The risk of cancer in the second degree relatives of a population-based series of children with soft tissue sarcoma was studied in relation to (i) various characteristics in these relatives, (ii) certain clinical features in the index children previously identified as risk factors for cancer in their first degree relatives. Overall there was a non-significant deficit of cancers in the second degree relatives (RR = 0.88) and cancer risk was unrelated to type or site of cancer, type of relative, or to risk factors in the index case. The findings indicate that although the families investigated may include a proportion with the Li-Fraumeni cancer family syndrome, the increased cancer risk already reported in the first degree relatives does not extent to second degree relatives in general. Nature Publishing Group 1991-06 /pmc/articles/PMC1972540/ /pubmed/2069851 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Hartley, A. L.
Birch, J. M.
Teare, M. D.
Blair, V.
Kelsey, A. M.
Cancer risk in second degree relatives of children with soft tissue sarcoma.
title Cancer risk in second degree relatives of children with soft tissue sarcoma.
title_full Cancer risk in second degree relatives of children with soft tissue sarcoma.
title_fullStr Cancer risk in second degree relatives of children with soft tissue sarcoma.
title_full_unstemmed Cancer risk in second degree relatives of children with soft tissue sarcoma.
title_short Cancer risk in second degree relatives of children with soft tissue sarcoma.
title_sort cancer risk in second degree relatives of children with soft tissue sarcoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1972540/
https://www.ncbi.nlm.nih.gov/pubmed/2069851
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