Cargando…
Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors
BACKGROUND: Passion flower (Passiflora incarnata) is used in traditional medicine of Europe and South America to treat anxiety, insomnia and seizure. Recently, it has shown antianxiety and sedative effects in human. METHODS: In this study, anticonvulsant effects of hydro- alcoholic extract of Passif...
Autores principales: | , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1973074/ https://www.ncbi.nlm.nih.gov/pubmed/17686156 http://dx.doi.org/10.1186/1472-6882-7-26 |
_version_ | 1782135033661751296 |
---|---|
author | Nassiri-Asl, Marjan Shariati-Rad, Schwann Zamansoltani, Farzaneh |
author_facet | Nassiri-Asl, Marjan Shariati-Rad, Schwann Zamansoltani, Farzaneh |
author_sort | Nassiri-Asl, Marjan |
collection | PubMed |
description | BACKGROUND: Passion flower (Passiflora incarnata) is used in traditional medicine of Europe and South America to treat anxiety, insomnia and seizure. Recently, it has shown antianxiety and sedative effects in human. METHODS: In this study, anticonvulsant effects of hydro- alcoholic extract of Passiflora, Pasipay, were examined by using pentylentetrazole model (PTZ) on mice. Pasipay, diazepam, and normal saline were injected intraperitoneally at the doses 0.4–0.05 mg/kg, 0.5–1 mg/kg and 10 ml/kg respectively 30 minutes before PTZ (90 mg/kg, i.p). The time taken before the onset of clonic convulsions, the duration of colonic convulsions, and the percentage of seizure and mortality protection were recorded. For investigating the mechanism of Pasipay, flumazenil (2 mg/kg, i.p) and naloxone (5 mg/kg, i.p) were also injected 5 minutes before Pasipay. RESULTS: An ED(50 )value of Pasipay in the PTZ model was 0.23 mg/kg (%95 CL: 0.156, 0.342). Pasipay at the dose of 0.4 mg/kg prolonged the onset time of seizure and decreased the duration of seizures compared to saline group (p < 0.001). At the dose of 0.4 mg/kg, seizure and mortality protection percent were 100%. Flumazenil and naloxone could suppress anticonvulsant effects of Pasipay. CONCLUSION: It seems that Pasipay could be useful for treatment absence seizure and these effects may be related to effect of it on GABAergic and opioid systems. More studies are needed in order to investigate its exact mechanism. |
format | Text |
id | pubmed-1973074 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-19730742007-09-08 Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors Nassiri-Asl, Marjan Shariati-Rad, Schwann Zamansoltani, Farzaneh BMC Complement Altern Med Research Article BACKGROUND: Passion flower (Passiflora incarnata) is used in traditional medicine of Europe and South America to treat anxiety, insomnia and seizure. Recently, it has shown antianxiety and sedative effects in human. METHODS: In this study, anticonvulsant effects of hydro- alcoholic extract of Passiflora, Pasipay, were examined by using pentylentetrazole model (PTZ) on mice. Pasipay, diazepam, and normal saline were injected intraperitoneally at the doses 0.4–0.05 mg/kg, 0.5–1 mg/kg and 10 ml/kg respectively 30 minutes before PTZ (90 mg/kg, i.p). The time taken before the onset of clonic convulsions, the duration of colonic convulsions, and the percentage of seizure and mortality protection were recorded. For investigating the mechanism of Pasipay, flumazenil (2 mg/kg, i.p) and naloxone (5 mg/kg, i.p) were also injected 5 minutes before Pasipay. RESULTS: An ED(50 )value of Pasipay in the PTZ model was 0.23 mg/kg (%95 CL: 0.156, 0.342). Pasipay at the dose of 0.4 mg/kg prolonged the onset time of seizure and decreased the duration of seizures compared to saline group (p < 0.001). At the dose of 0.4 mg/kg, seizure and mortality protection percent were 100%. Flumazenil and naloxone could suppress anticonvulsant effects of Pasipay. CONCLUSION: It seems that Pasipay could be useful for treatment absence seizure and these effects may be related to effect of it on GABAergic and opioid systems. More studies are needed in order to investigate its exact mechanism. BioMed Central 2007-08-08 /pmc/articles/PMC1973074/ /pubmed/17686156 http://dx.doi.org/10.1186/1472-6882-7-26 Text en Copyright © 2007 Nassiri-Asl et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Nassiri-Asl, Marjan Shariati-Rad, Schwann Zamansoltani, Farzaneh Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors |
title | Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors |
title_full | Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors |
title_fullStr | Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors |
title_full_unstemmed | Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors |
title_short | Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors |
title_sort | anticonvulsant effects of aerial parts of passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1973074/ https://www.ncbi.nlm.nih.gov/pubmed/17686156 http://dx.doi.org/10.1186/1472-6882-7-26 |
work_keys_str_mv | AT nassiriaslmarjan anticonvulsanteffectsofaerialpartsofpassifloraincarnataextractinmiceinvolvementofbenzodiazepineandopioidreceptors AT shariatiradschwann anticonvulsanteffectsofaerialpartsofpassifloraincarnataextractinmiceinvolvementofbenzodiazepineandopioidreceptors AT zamansoltanifarzaneh anticonvulsanteffectsofaerialpartsofpassifloraincarnataextractinmiceinvolvementofbenzodiazepineandopioidreceptors |