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Knockdown of the bovine prion gene PRNP by RNA interference (RNAi) technology

BACKGROUND: Since prion gene-knockout mice do not contract prion diseases and animals in which production of prion protein (PrP) is reduced by half are resistant to the disease, we hypothesized that bovine animals with reduced PrP would be tolerant to BSE. Hence, attempts were made to produce bovine...

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Detalles Bibliográficos
Autores principales:	Sutou, Shizuyo, Kunishi, Miho, Kudo, Toshiyuki, Wongsrikeao, Pimprapar, Miyagishi, Makoto, Otoi, Takeshige
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976095/ https://www.ncbi.nlm.nih.gov/pubmed/17655742 http://dx.doi.org/10.1186/1472-6750-7-44

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