Cell-penetrating peptides as transporters for morpholino oligomers: effects of amino acid composition on intracellular delivery and cytotoxicity

Arginine-rich cell-penetrating peptides (CPPs) are promising transporters for intracellular delivery of antisense morpholino oligomers (PMO). Here, we determined the effect of L-arginine, D-arginine and non-α amino acids on cellular uptake, splice-correction activity, cellular toxicity and serum bin...

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Detalles Bibliográficos
Autores principales: Wu, Rebecca P., Youngblood, Derek S., Hassinger, Jed N., Lovejoy, Candace E., Nelson, Michelle H., Iversen, Patrick L., Moulton, Hong M.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976451/
https://www.ncbi.nlm.nih.gov/pubmed/17670797
http://dx.doi.org/10.1093/nar/gkm478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976451/
https://www.ncbi.nlm.nih.gov/pubmed/17670797
http://dx.doi.org/10.1093/nar/gkm478

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