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Oxytocin in the Circadian Timing of Birth
BACKGROUND: The molecular components determining the timing for birth remain an incompletely characterized aspect of reproduction, with important conceptual and therapeutic ramifications for management of preterm, post-term and arrested labor. METHODOLOGY/PRINCIPAL FINDINGS: To test the hypothesis t...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976559/ https://www.ncbi.nlm.nih.gov/pubmed/17895964 http://dx.doi.org/10.1371/journal.pone.0000922 |
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author | Roizen, Jeffrey Luedke, Christina E. Herzog, Erik D. Muglia, Louis J. |
author_facet | Roizen, Jeffrey Luedke, Christina E. Herzog, Erik D. Muglia, Louis J. |
author_sort | Roizen, Jeffrey |
collection | PubMed |
description | BACKGROUND: The molecular components determining the timing for birth remain an incompletely characterized aspect of reproduction, with important conceptual and therapeutic ramifications for management of preterm, post-term and arrested labor. METHODOLOGY/PRINCIPAL FINDINGS: To test the hypothesis that oxytocin mediates circadian regulation of birth, we evaluated parturition timing following shifts in light cycles in oxytocin (OT)-deficient mice. We find that, in contrast to wild type mice that do not shift the timing of birth following a 6-h advance or delay in the light cycle, OT-deficient mice delivered at random times of day. Moreover, shifts in the light-dark cycle of gravid wild type mice have little impact on the pattern of circadian oxytocin release. CONCLUSIONS/SIGNIFICANCE: Our results demonstrate oxytocin plays a critical role in minimizing labor disruption due to circadian clock resetting. |
format | Text |
id | pubmed-1976559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-19765592007-09-26 Oxytocin in the Circadian Timing of Birth Roizen, Jeffrey Luedke, Christina E. Herzog, Erik D. Muglia, Louis J. PLoS One Research Article BACKGROUND: The molecular components determining the timing for birth remain an incompletely characterized aspect of reproduction, with important conceptual and therapeutic ramifications for management of preterm, post-term and arrested labor. METHODOLOGY/PRINCIPAL FINDINGS: To test the hypothesis that oxytocin mediates circadian regulation of birth, we evaluated parturition timing following shifts in light cycles in oxytocin (OT)-deficient mice. We find that, in contrast to wild type mice that do not shift the timing of birth following a 6-h advance or delay in the light cycle, OT-deficient mice delivered at random times of day. Moreover, shifts in the light-dark cycle of gravid wild type mice have little impact on the pattern of circadian oxytocin release. CONCLUSIONS/SIGNIFICANCE: Our results demonstrate oxytocin plays a critical role in minimizing labor disruption due to circadian clock resetting. Public Library of Science 2007-09-26 /pmc/articles/PMC1976559/ /pubmed/17895964 http://dx.doi.org/10.1371/journal.pone.0000922 Text en Roizen et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Roizen, Jeffrey Luedke, Christina E. Herzog, Erik D. Muglia, Louis J. Oxytocin in the Circadian Timing of Birth |
title | Oxytocin in the Circadian Timing of Birth |
title_full | Oxytocin in the Circadian Timing of Birth |
title_fullStr | Oxytocin in the Circadian Timing of Birth |
title_full_unstemmed | Oxytocin in the Circadian Timing of Birth |
title_short | Oxytocin in the Circadian Timing of Birth |
title_sort | oxytocin in the circadian timing of birth |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976559/ https://www.ncbi.nlm.nih.gov/pubmed/17895964 http://dx.doi.org/10.1371/journal.pone.0000922 |
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