An immunohistological study of testicular germ cell tumours using two different monoclonal antibodies against placental alkaline phosphatase.

Using two monoclonal antibodies directed against placental alkaline phosphatase (H17E2 and D20L) the immunohistological staining of testicular germ cell tumours was compared with that of a wide range of normal and malignant tissues. All seminomas and malignant teratomas tested gave strong positive l...

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Autores principales: Epenetos, A. A., Travers, P., Gatter, K. C., Oliver, R. D., Mason, D. Y., Bodmer, W. F.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1984
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976671/
https://www.ncbi.nlm.nih.gov/pubmed/6362705
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author Epenetos, A. A.
Travers, P.
Gatter, K. C.
Oliver, R. D.
Mason, D. Y.
Bodmer, W. F.
author_facet Epenetos, A. A.
Travers, P.
Gatter, K. C.
Oliver, R. D.
Mason, D. Y.
Bodmer, W. F.
author_sort Epenetos, A. A.
collection PubMed
description Using two monoclonal antibodies directed against placental alkaline phosphatase (H17E2 and D20L) the immunohistological staining of testicular germ cell tumours was compared with that of a wide range of normal and malignant tissues. All seminomas and malignant teratomas tested gave strong positive labelling with H17E2 but were either negative or only patchily positive with D20L. Neither antibody gave any positive reaction on the normal tissues tested. All other malignancies were negative with both antibodies apart from two cases of ovarian and one case of endometrical cancer (strongly stained by H17E2) and three cases of colonic carcinoma (weakly and patchily stained by both H17E2 and D20L). This indicates that germ cell neoplasms generally express a form of placental alkaline phosphatase recognised by antibody H17E2. IMAGES:
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spelling pubmed-19766712009-09-10 An immunohistological study of testicular germ cell tumours using two different monoclonal antibodies against placental alkaline phosphatase. Epenetos, A. A. Travers, P. Gatter, K. C. Oliver, R. D. Mason, D. Y. Bodmer, W. F. Br J Cancer Research Article Using two monoclonal antibodies directed against placental alkaline phosphatase (H17E2 and D20L) the immunohistological staining of testicular germ cell tumours was compared with that of a wide range of normal and malignant tissues. All seminomas and malignant teratomas tested gave strong positive labelling with H17E2 but were either negative or only patchily positive with D20L. Neither antibody gave any positive reaction on the normal tissues tested. All other malignancies were negative with both antibodies apart from two cases of ovarian and one case of endometrical cancer (strongly stained by H17E2) and three cases of colonic carcinoma (weakly and patchily stained by both H17E2 and D20L). This indicates that germ cell neoplasms generally express a form of placental alkaline phosphatase recognised by antibody H17E2. IMAGES: Nature Publishing Group 1984-01 /pmc/articles/PMC1976671/ /pubmed/6362705 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Epenetos, A. A.
Travers, P.
Gatter, K. C.
Oliver, R. D.
Mason, D. Y.
Bodmer, W. F.
An immunohistological study of testicular germ cell tumours using two different monoclonal antibodies against placental alkaline phosphatase.
title An immunohistological study of testicular germ cell tumours using two different monoclonal antibodies against placental alkaline phosphatase.
title_full An immunohistological study of testicular germ cell tumours using two different monoclonal antibodies against placental alkaline phosphatase.
title_fullStr An immunohistological study of testicular germ cell tumours using two different monoclonal antibodies against placental alkaline phosphatase.
title_full_unstemmed An immunohistological study of testicular germ cell tumours using two different monoclonal antibodies against placental alkaline phosphatase.
title_short An immunohistological study of testicular germ cell tumours using two different monoclonal antibodies against placental alkaline phosphatase.
title_sort immunohistological study of testicular germ cell tumours using two different monoclonal antibodies against placental alkaline phosphatase.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976671/
https://www.ncbi.nlm.nih.gov/pubmed/6362705
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