Intercellular junctions of methylcholanthrene-induced rat skin basocellular and squamous carcinomas.

The occurrence of different intercellular junctions in epithelial rat skin tumours induced by methylcholanthrene was investigated using thin sections and freeze-fracture replicas examined by electron microscopy. Tumours which appeared first were basal cell carcinomas. Later, different tumours of hai...

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Detalles Bibliográficos
Autores principales: Horak, E., Lelkes, G., Sugar, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1984
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976719/
https://www.ncbi.nlm.nih.gov/pubmed/6722012
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author Horak, E.
Lelkes, G.
Sugar, J.
author_facet Horak, E.
Lelkes, G.
Sugar, J.
author_sort Horak, E.
collection PubMed
description The occurrence of different intercellular junctions in epithelial rat skin tumours induced by methylcholanthrene was investigated using thin sections and freeze-fracture replicas examined by electron microscopy. Tumours which appeared first were basal cell carcinomas. Later, different tumours of hair follicle and of sebaceous gland origin were formed. Finally, in the majority of tumours a squamous component evolved. Metastases developed from the squamous carcinomas exclusively. Desmosomes and gap junctions were detected in basal cell carcinomas whereas, in squamous carcinomas, tight junctions were also seen. While all three types of junction were found in the primary squamous tumours, the tumour metastases in lymph nodes and lungs contained only desmosomes. IMAGES:
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spelling pubmed-19767192009-09-10 Intercellular junctions of methylcholanthrene-induced rat skin basocellular and squamous carcinomas. Horak, E. Lelkes, G. Sugar, J. Br J Cancer Research Article The occurrence of different intercellular junctions in epithelial rat skin tumours induced by methylcholanthrene was investigated using thin sections and freeze-fracture replicas examined by electron microscopy. Tumours which appeared first were basal cell carcinomas. Later, different tumours of hair follicle and of sebaceous gland origin were formed. Finally, in the majority of tumours a squamous component evolved. Metastases developed from the squamous carcinomas exclusively. Desmosomes and gap junctions were detected in basal cell carcinomas whereas, in squamous carcinomas, tight junctions were also seen. While all three types of junction were found in the primary squamous tumours, the tumour metastases in lymph nodes and lungs contained only desmosomes. IMAGES: Nature Publishing Group 1984-05 /pmc/articles/PMC1976719/ /pubmed/6722012 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Horak, E.
Lelkes, G.
Sugar, J.
Intercellular junctions of methylcholanthrene-induced rat skin basocellular and squamous carcinomas.
title Intercellular junctions of methylcholanthrene-induced rat skin basocellular and squamous carcinomas.
title_full Intercellular junctions of methylcholanthrene-induced rat skin basocellular and squamous carcinomas.
title_fullStr Intercellular junctions of methylcholanthrene-induced rat skin basocellular and squamous carcinomas.
title_full_unstemmed Intercellular junctions of methylcholanthrene-induced rat skin basocellular and squamous carcinomas.
title_short Intercellular junctions of methylcholanthrene-induced rat skin basocellular and squamous carcinomas.
title_sort intercellular junctions of methylcholanthrene-induced rat skin basocellular and squamous carcinomas.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976719/
https://www.ncbi.nlm.nih.gov/pubmed/6722012
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AT lelkesg intercellularjunctionsofmethylcholanthreneinducedratskinbasocellularandsquamouscarcinomas
AT sugarj intercellularjunctionsofmethylcholanthreneinducedratskinbasocellularandsquamouscarcinomas

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