Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy.

We have investigated X-ray survival parameters and repair of potentially lethal damage ( PLDR ) in ten early passage squamous cell carcinoma cell lines derived from patients who were biopsied before initiation of radiotherapy or after radiation therapy failure. Radiosensitivity (D0) ranged from 1.07...

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Detalles Bibliográficos
Autores principales: Weichselbaum, R., Dahlberg, W., Little, J. B., Ervin, T. J., Miller, D., Hellman, S., Rheinwald, J. G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1984
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976725/
https://www.ncbi.nlm.nih.gov/pubmed/6722007
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author Weichselbaum, R.
Dahlberg, W.
Little, J. B.
Ervin, T. J.
Miller, D.
Hellman, S.
Rheinwald, J. G.
author_facet Weichselbaum, R.
Dahlberg, W.
Little, J. B.
Ervin, T. J.
Miller, D.
Hellman, S.
Rheinwald, J. G.
author_sort Weichselbaum, R.
collection PubMed
description We have investigated X-ray survival parameters and repair of potentially lethal damage ( PLDR ) in ten early passage squamous cell carcinoma cell lines derived from patients who were biopsied before initiation of radiotherapy or after radiation therapy failure. Radiosensitivity (D0) ranged from 1.07 to 1.93 (Gy), extrapolation numbers (-n) from 1.17 to 2.14 and PLD recovery at 24 h from 1.4 to 20.3. Despite significant differences in these parameters amongst the cell lines, a firm correlation between radiocurability and any individual radiobiological parameter could not be established. Our data suggest that the mechanisms associated with radioresistance are complex and that any single radiobiological parameter may not predict clinical success or failure.
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spelling pubmed-19767252009-09-10 Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy. Weichselbaum, R. Dahlberg, W. Little, J. B. Ervin, T. J. Miller, D. Hellman, S. Rheinwald, J. G. Br J Cancer Research Article We have investigated X-ray survival parameters and repair of potentially lethal damage ( PLDR ) in ten early passage squamous cell carcinoma cell lines derived from patients who were biopsied before initiation of radiotherapy or after radiation therapy failure. Radiosensitivity (D0) ranged from 1.07 to 1.93 (Gy), extrapolation numbers (-n) from 1.17 to 2.14 and PLD recovery at 24 h from 1.4 to 20.3. Despite significant differences in these parameters amongst the cell lines, a firm correlation between radiocurability and any individual radiobiological parameter could not be established. Our data suggest that the mechanisms associated with radioresistance are complex and that any single radiobiological parameter may not predict clinical success or failure. Nature Publishing Group 1984-05 /pmc/articles/PMC1976725/ /pubmed/6722007 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Weichselbaum, R.
Dahlberg, W.
Little, J. B.
Ervin, T. J.
Miller, D.
Hellman, S.
Rheinwald, J. G.
Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy.
title Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy.
title_full Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy.
title_fullStr Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy.
title_full_unstemmed Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy.
title_short Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy.
title_sort cellular x-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976725/
https://www.ncbi.nlm.nih.gov/pubmed/6722007
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