The effect of fibre size on the in vivo activity of UICC crocidolite.

Standard (UICC) crocidolite was subjected to ball milling to reduce the length of the fibre. These milled materials and the original standard sample were injected into the pleural cavity of rats to determine their ability to induce mesothelioma. Previous in vitro work on the same materials had sugge...

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Autores principales: Wagner, J. C., Griffiths, D. M., Hill, R. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1984
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976765/
https://www.ncbi.nlm.nih.gov/pubmed/6324841
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author Wagner, J. C.
Griffiths, D. M.
Hill, R. J.
author_facet Wagner, J. C.
Griffiths, D. M.
Hill, R. J.
author_sort Wagner, J. C.
collection PubMed
description Standard (UICC) crocidolite was subjected to ball milling to reduce the length of the fibre. These milled materials and the original standard sample were injected into the pleural cavity of rats to determine their ability to induce mesothelioma. Previous in vitro work on the same materials had suggested that biological activity was related to fibres greater than 6.5 microns in length and that the material milled for 4 and 8 h did not contain fibres in this range and was biologically inactive. The results of the animal work, however, did not follow this pattern; mesotheliomas occurred in rats in all treatment groups including the 4 and 8 h milled samples. Examination of the tissues and the dust recovered from them showed the presence of fibres greater than the suggested threshold. Attention is drawn to the problems associated with drawing conclusions from size distributions and in vitro studies without considering in vivo mechanisms. IMAGES:
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spelling pubmed-19767652009-09-10 The effect of fibre size on the in vivo activity of UICC crocidolite. Wagner, J. C. Griffiths, D. M. Hill, R. J. Br J Cancer Research Article Standard (UICC) crocidolite was subjected to ball milling to reduce the length of the fibre. These milled materials and the original standard sample were injected into the pleural cavity of rats to determine their ability to induce mesothelioma. Previous in vitro work on the same materials had suggested that biological activity was related to fibres greater than 6.5 microns in length and that the material milled for 4 and 8 h did not contain fibres in this range and was biologically inactive. The results of the animal work, however, did not follow this pattern; mesotheliomas occurred in rats in all treatment groups including the 4 and 8 h milled samples. Examination of the tissues and the dust recovered from them showed the presence of fibres greater than the suggested threshold. Attention is drawn to the problems associated with drawing conclusions from size distributions and in vitro studies without considering in vivo mechanisms. IMAGES: Nature Publishing Group 1984-04 /pmc/articles/PMC1976765/ /pubmed/6324841 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Wagner, J. C.
Griffiths, D. M.
Hill, R. J.
The effect of fibre size on the in vivo activity of UICC crocidolite.
title The effect of fibre size on the in vivo activity of UICC crocidolite.
title_full The effect of fibre size on the in vivo activity of UICC crocidolite.
title_fullStr The effect of fibre size on the in vivo activity of UICC crocidolite.
title_full_unstemmed The effect of fibre size on the in vivo activity of UICC crocidolite.
title_short The effect of fibre size on the in vivo activity of UICC crocidolite.
title_sort effect of fibre size on the in vivo activity of uicc crocidolite.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976765/
https://www.ncbi.nlm.nih.gov/pubmed/6324841
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