Prostaglandins in human mammary cancer.

Prostaglandins E2 and F2 alpha (PGE2 and PGF2 alpha) were measured by Gas Liquid Chromatography-Mass Spectrometry (GLC-MS) in extracts of 100 human mammary carcinomas. All tumours contained measurable amounts of both prostaglandins but wide variations between individual tumours were observed. Values...

Descripción completa

Detalles Bibliográficos
Autores principales: Watson, D. M., Kelly, R. W., Hawkins, R. A., Miller, W. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1984
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976779/
https://www.ncbi.nlm.nih.gov/pubmed/6585216
_version_ 1782135125973139456
author Watson, D. M.
Kelly, R. W.
Hawkins, R. A.
Miller, W. R.
author_facet Watson, D. M.
Kelly, R. W.
Hawkins, R. A.
Miller, W. R.
author_sort Watson, D. M.
collection PubMed
description Prostaglandins E2 and F2 alpha (PGE2 and PGF2 alpha) were measured by Gas Liquid Chromatography-Mass Spectrometry (GLC-MS) in extracts of 100 human mammary carcinomas. All tumours contained measurable amounts of both prostaglandins but wide variations between individual tumours were observed. Values for PGE2 ranged from 7 to 762 ng g-1 tissue with a median of 100 ng g-1 tissue. Values for PGF2 alpha ranged from 3 to 475 ng g-1 tissue (median 60 ng g-1 tissue). There was a highly significant positive correlation between amounts of the 2 prostaglandins in individual tumours. Amounts of both PGE2 and PGF2 alpha were not significantly related to the menopausal status of the patients or the presence of oestrogen and progesterone receptors.
format Text
id pubmed-1976779
institution National Center for Biotechnology Information
language English
publishDate 1984
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-19767792009-09-10 Prostaglandins in human mammary cancer. Watson, D. M. Kelly, R. W. Hawkins, R. A. Miller, W. R. Br J Cancer Research Article Prostaglandins E2 and F2 alpha (PGE2 and PGF2 alpha) were measured by Gas Liquid Chromatography-Mass Spectrometry (GLC-MS) in extracts of 100 human mammary carcinomas. All tumours contained measurable amounts of both prostaglandins but wide variations between individual tumours were observed. Values for PGE2 ranged from 7 to 762 ng g-1 tissue with a median of 100 ng g-1 tissue. Values for PGF2 alpha ranged from 3 to 475 ng g-1 tissue (median 60 ng g-1 tissue). There was a highly significant positive correlation between amounts of the 2 prostaglandins in individual tumours. Amounts of both PGE2 and PGF2 alpha were not significantly related to the menopausal status of the patients or the presence of oestrogen and progesterone receptors. Nature Publishing Group 1984-04 /pmc/articles/PMC1976779/ /pubmed/6585216 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Watson, D. M.
Kelly, R. W.
Hawkins, R. A.
Miller, W. R.
Prostaglandins in human mammary cancer.
title Prostaglandins in human mammary cancer.
title_full Prostaglandins in human mammary cancer.
title_fullStr Prostaglandins in human mammary cancer.
title_full_unstemmed Prostaglandins in human mammary cancer.
title_short Prostaglandins in human mammary cancer.
title_sort prostaglandins in human mammary cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976779/
https://www.ncbi.nlm.nih.gov/pubmed/6585216
work_keys_str_mv AT watsondm prostaglandinsinhumanmammarycancer
AT kellyrw prostaglandinsinhumanmammarycancer
AT hawkinsra prostaglandinsinhumanmammarycancer
AT millerwr prostaglandinsinhumanmammarycancer

Ejemplares similares